Evidence map›Paper›PMID 28650106›Full record

ArticleJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research2017

DOK3 Modulates Bone Remodeling by Negatively Regulating Osteoclastogenesis and Positively Regulating Osteoblastogenesis.

Xiaofeng Cai, Junjie Xing, Courtney L Long, Qisheng Peng, Mary Beth Humphrey

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Porphyromonas gingivalis Activation of Tumor-Associated Macrophages via DOK3 Promotes Recurrence of Oral Squamous Cell Carcinoma.Medical science monitor : international medical journal of experimental and clinical research · 2022
    Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Review
  11. Frontiers in bioengineering and biotechnology · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 3 countries.

Xiaofeng CaiDepartment of Medicine, University of Oklahoma Health Science Center, Oklahoma City, OK, USA.
Junjie XingDepartment of Medicine, University of Oklahoma Health Science Center, Oklahoma City, OK, USA.
Courtney L LongDepartment of Medicine, University of Oklahoma Health Science Center, Oklahoma City, OK, USA.
Qisheng PengKey Laboratory for Zoonosis Research, Jilin University, Changchun, China.
Mary Beth HumphreyDepartment of Medicine, University of Oklahoma Health Science Center, Oklahoma City, OK, USA.
University of Oklahoma Health Sciences Center · USJilin University · CN

Funding

UAB Core Center for Musculoskeletal DisordersP30AR046031 · NIAMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GILBERT, SHAWN ROBERT · 2001 to 2010
$5.6M
Calcium Regulation in OsteoclastsR01AR064211 · NIAMS · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI HUMPHREY, MARY BETH, TSIOKAS, LEONIDAS · 2013 to 2017
$2.1M
Mechanism of ITAM Signal Regulation in OsteoclastsR01DE019398 · NIDCR · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI HUMPHREY, MARY BETH · 2008 to 2012
$1.3M
NIAMS NIH HHS P30 AR046031NIAMS NIH HHS R01 AR064211NIDCR NIH HHS R01 DE019398
6 · The paper itself

Abstract

Osteoclastogenesis is essential for bone remodeling and normal skeletal maintenance. Receptor activator of NF-κB ligand (RANKL) promotes osteoclast differentiation and function but requires costimulation of immunoreceptor tyrosine-based activation motif (ITAM)-coupled immunoreceptors. Triggering receptor expressed on myeloid cells-2 (TREM2) coupled to ITAM-adaptor protein DNAX activation protein 12kDA (DAP12) provides costimulation of intracellular calcium signaling during osteoclastogenesis. Previously, we found that downstream of kinase-3 (DOK3) physically associates with DAP12 to inhibit toll-like receptor (TLR)-induced inflammatory signaling in macrophages. However, whether and how DOK3 modulates DAP12-dependent osteoclastogenesis is unknown and the focus of this study. Bone microarchitecture and histology of sex- and age-matched wild-type (WT) and DOK3-deficient (DOK3

Indexed as

Bone RemodelingOsteogenesisAdaptor Proteins, Signal TransducingAnimalsBone Marrow CellsBone ResorptionCell DifferentiationCell ProliferationMacrophage Colony-Stimulating FactorMacrophagesMembrane GlycoproteinsMiceMice, Inbred C57BLOsteoblastsOsteoclastsOsteoporosisAdaptor Proteins, Signal TransducingDok3 protein, mouseMacrophage Colony-Stimulating FactorMembrane GlycoproteinsRANK LigandReceptors, ImmunologicTrem2 protein, mouseTyrobp protein, mouseDAP12DOK3M-CSFRANKLTREM2

Identifiers

PMID28650106
PMCPMC5685877
OpenAlexW2713680040

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.