ArticlePhysical biology2017
Modeling mechanical interactions in growing populations of rod-shaped bacteria.
Article in Physical biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 36 citations in OpenAlex.
- Computational model of fractal interface formation in bacterial biofilms.Physical review. E · 2025Article
- Dissecting the physics of bacterial biofilms with agent-based simulations.Current opinion in solid state & materials science · 2025Article
- Effects of curvature on growing films of microorganisms.Biophysical journal · 2025Article
- Is it selfish to be filamentous in biofilms? Individual-based modeling links microbial growth strategies with morphology using the new and modular iDynoMiCS 2.0.PLoS computational biology · 2024Article
- Spatial exclusion leads to "tug-of-war" ecological dynamics between competing species within microchannels.PLoS computational biology · 2023Article
- Mutant-Dependent Local Orientational Correlation in Biofilms ofInternational journal of molecular sciences · 2023Article
- Emergent spatiotemporal population dynamics with cell-length control of synthetic microbial consortia.PLoS computational biology · 2021Article
- Agent Based Models of Polymicrobial Biofilms and the Microbiome-A Review.Microorganisms · 2021Review
- Confinement-induced self-organization in growing bacterial colonies.Science advances · 2021Article
- Novel Tunable Spatio-Temporal Patterns From a Simple Genetic Oscillator Circuit.Frontiers in bioengineering and biotechnology · 2020Article
- Long-range temporal coordination of gene expression in synthetic microbial consortia.Nature chemical biology · 2019Article
- Spatiotemporal Dynamics of Synthetic Microbial Consortia in Microfluidic Devices.ACS synthetic biology · 2019Article
- Moran Model of Spatial Alignment in Microbial Colonies.Physica D. Nonlinear phenomena · 2019Article
- Statistics of noisy growth with mechanical feedback in elastic tissues.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Modeling cell population dynamics.In silico biology · 2019Article
- Individual Based Model Links Thermodynamics, Chemical Speciation and Environmental Conditions to Microbial Growth.Frontiers in microbiology · 2019Article
- Computer simulation study of early bacterial biofilm development.Scientific reports · 2018Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Advances in synthetic biology allow us to engineer bacterial collectives with pre-specified characteristics. However, the behavior of these collectives is difficult to understand, as cellular growth and division as well as extra-cellular fluid flow lead to complex, changing arrangements of cells within the population. To rationally engineer and control the behavior of cell collectives we need theoretical and computational tools to understand their emergent spatiotemporal dynamics. Here, we present an agent-based model that allows growing cells to detect and respond to mechanical interactions. Crucially, our model couples the dynamics of cell growth to the cell's environment: Mechanical constraints can affect cellular growth rate and a cell may alter its behavior in response to these constraints. This coupling links the mechanical forces that influence cell growth and emergent behaviors in cell assemblies. We illustrate our approach by showing how mechanical interactions can impact the dynamics of bacterial collectives growing in microfluidic traps.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.