ArticleJournal of the American Geriatrics Society2017
Polypharmacy and Gait Performance in Community-dwelling Older Adults.
Article in Journal of the American Geriatrics Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.
- The Association Between Polypharmacy and Physical Function in Older Adults: a Systematic Review.Journal of general internal medicine · 2019Pooled it
- Polypharmacy Increases Risk of Dyspnea Among Adults With Serious, Life-Limiting Diseases.The American journal of hospice & palliative care · 2020Trial
- Turns and Turn-Related Falls: Stepping on a Rotating Platform as a Potential Approach to Foster Adapted Muscular and Neural Plasticity in Fragile Persons and Patients with Motor Impairment.Brain sciences · 2026Article
- Effect of Inpatient Pharmacist-Led Medication Reconciliations on Medication-Related Interventions in Intensive Care Unit Recovery Centers.Hospital pharmacy · 2024Article
- Association of Healthy Lifestyle and Incident Polypharmacy.The American journal of medicine · 2024Article
- Effect modification of polypharmacy on incident frailty by chronic kidney disease in older adults.BMC geriatrics · 2024Article
- Incidence of Motoric Cognitive Risk Syndrome and Associated Factors in Older Adults in Türkiye.Balkan medical journal · 2024Article
- Faster Walking Speeds Require Greater Activity from the Primary Motor Cortex in Older Adults Compared to Younger Adults.Sensors (Basel, Switzerland) · 2023Article
- Doing housework and having regular daily routine standing out as factors associate with physical function in the older people.Frontiers in public health · 2023Article
- Medication use problems among older adults at a primary care: A narrative of literature review.Aging medicine (Milton (N.S.W)) · 2022Review
- Frailty Risks of Prescription Analgesics and Sedatives across Frailty Models: the Health and Retirement Study.Drugs & aging · 2022Article
- Association of personality traits with polypharmacy among community-dwelling older adults in Japan: a cross-sectional analysis of data from the SONIC study.BMC geriatrics · 2022Article
- Genome-Wide Analysis inGenes · 2022Article
- A concerning trend in geriatric pharmacy that merits evidence-based intervention.Proceedings (Baylor University. Medical Center) · 2022Article
- Non-random relations in drug use expressed as patterns comprising prescription and over-the-counter drugs in multimorbid elderly patients in primary care: Data of the exploratory analysis of the multicentre, observational cohort study MultiCare.The European journal of general practice · 2021Observational
- Fat-Fit Patterns, Drug Consumption, and Polypharmacy in Older Adults: The EXERNET Multi-Center Study.Nutrients · 2021Article
- Polypharmacy in older adults: a narrative review of definitions, epidemiology and consequences.European geriatric medicine · 2021Review
- Combined diabetes and arthritis are associated with declined gait speed.Clinical rheumatology · 2021Article
- Does self-report of multimorbidity in later life predict impaired physical functioning, and might this be useful in clinical practice?Aging clinical and experimental research · 2020Article
- Motoric Cognitive Risk Syndrome in Polypharmacy.Journal of the American Geriatrics Society · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesTo examine the relationship between polypharmacy and gait performance during simple (normal walk (NW)) and complex (walking while talking (WWT)) locomotion.
designCross-sectional.
settingCommunity.
participantsCommunity-dwelling older adults (N = 482). MEASUREMENTS: Polypharmacy, defined as use of five or more medications and a cohort-specific alternate definition of eight or more medications, was examined. Velocity (cm/s) measured quantitatively during NW and WWT conditions.
resultsThe 164 participants (34%) with polypharmacy of five or more medications were older (77.0 ± 6.6 vs 76.0 ± 6.4) and more likely to have hypertension, congestive heart failure, diabetes mellitus, myocardial infarction, and higher body mass index (BMI) and to have fallen within the last year than the remaining 318 without polypharmacy and walked 6 cm/s slower (P = .004) during NW and 4 cm/s slower during WWT (P = .07), adjusting for age, sex, and education. Group differences were not statistically significant after adjusting for comorbidities. Prevalence of polypharmacy of eight or more medications was 10%. This group walked 11 cm/s slower during NW (P < .001) and 8.6 cm/s slower during WWT (P = .01) than those without polypharmacy, adjusted for age, sex, and education. Participants taking eight or more medications had slower NW (8.5 cm/s; P = .01), and WWT (6.9 cm/s; P = .07), compared to those without polypharmacy, adjusting for comorbidities. Adjustments for BMI, high-risk drugs, falls, and comorbidities yielded slower NW (9.4 cm/s, P = .005) and WWT (7.9 cm/s, P = .04 among those with polypharmacy compared to those without polypharmacy).
conclusionThese results suggest an association between polypharmacy and locomotion that medical comorbidities only partly explained.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.