ArticleThe Journal of comparative neurology2017
Neuronal aromatase expression in pain processing regions of the medullary and spinal cord dorsal horn.
Article in The Journal of comparative neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 14 citations in OpenAlex.
- Dual Role of the Spinal Endocannabinoid System in Response to Noxious Stimuli: Antinociceptive Pathways and Neuropathic Pain Mechanisms.International journal of molecular sciences · 2025Review
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- Article
- Cholesterol-dependent LXR transcription factor activity represses pronociceptive effects of estrogen in sensory neurons and pain induced by myelin basic protein fragments.Brain, behavior, & immunity - health · 2024Article
- Naringenin stimulates aromatase expression and alleviates the clinical and histopathological findings of experimental autoimmune encephalomyelitis in C57bl6 mice.Histochemistry and cell biology · 2023Article
- Neuroestradiol regulation of ventromedial hypothalamic nucleus 5'-AMP-activated protein kinase activity and counterregulatory hormone secretion in hypoglycemic male versus female rats.AIMS neuroscience · 2021Article
- Ablation of spinal cord estrogen receptor α-expressing interneurons reduces chemically induced modalities of pain and itch.The Journal of comparative neurology · 2020Article
- Non-reproductive Functions of Aromatase in the Central Nervous System Under Physiological and Pathological Conditions.Cellular and molecular neurobiology · 2019Review
- Sex Differences in Estradiol Secretion by Trigeminal Brainstem Neurons.Frontiers in integrative neuroscience · 2019Article
- Expression of aromatase in the rostral ventromedial medulla and its role in the regulation of visceral pain.CNS neuroscience & therapeutics · 2017Article
- Neuronal aromatase expression in pain processing regions of the medullary and spinal cord dorsal horn.The Journal of comparative neurology · 2017Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
In both acute and chronic pain conditions, women tend to be more sensitive than men. This sex difference may be regulated by estrogens, such as estradiol, that are synthesized in the spinal cord and brainstem and act locally to influence pain processing. To identify a potential cellular source of local estrogen, here we examined the expression of aromatase, the enzyme that catalyzes the conversion of testosterone to estradiol. Our studies focused on primary afferent neurons and on their central targets in the spinal cord and medulla as well as in the nucleus of the solitary tract, the target of nodose ganglion-derived visceral afferents. Immunohistochemical staining in an aromatase reporter mouse revealed that many neurons in laminae I and V of the spinal cord dorsal horn and caudal spinal trigeminal nucleus and in the nucleus of the solitary tract express aromatase. The great majority of these cells also express inhibitory interneuron markers. We did not find sex differences in aromatase expression and neither the pattern nor the number of neurons changed in a sciatic nerve transection model of neuropathic pain or in the Complete Freund's adjuvant model of inflammatory pain. A few aromatase neurons express Fos after cheek injection of capsaicin, formalin, or chloroquine. In total, given their location, these aromatase neurons are poised to engage nociceptive circuits, whether it is through local estrogen synthesis or inhibitory neurotransmitter release.
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Registered trials
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