Evidence map›Paper›PMID 28649675›Full record

ArticleInsights in allergy, asthma & bronchitis2016

Prenatal Omega-3 Supplementation and Eczema Risk among Offspring at Age 36 Months.

D Berman, C Clinton, R Limb, E C Somers, V Romero, E Mozurkewich

Registry-linked trialOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Insights in allergy, asthma & bronchitis, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00711971 (Does EPA or DHA Prevent Depressive Symptoms in Pregnancy and Postpartum?), which is not on this map. Cited by 10 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 6 pooled it
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00711971 phase2 / phase3completednot on this map

Does EPA or DHA Prevent Depressive Symptoms in Pregnancy and Postpartum?

TypeinterventionalSponsorUniversity of MichiganRan2008 to 2013Enrolled126ConditionsDepressionArmsEPA-rich fish oil supplement, DHA-rich fish oil supplement, placebo
3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 6 syntheses or guidelines pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Dietary factors during pregnancy and atopic outcomes in childhood: A systematic review from the European Academy of Allergy and Clinical Immunology.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2020
    Pooled it
  6. Omega-3 fatty acid addition during pregnancy.The Cochrane database of systematic reviews · 2018
    Pooled it
  7. Review
  8. S3 guideline Allergy Prevention.Allergologie select · 2022
    Article
  9. Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

D BermanDepartment of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, University of Michigan, Ann Arbor, MI, United States.
C ClintonDepartment of Obstetrics and Gynecology, Cornell University, New York NY, United States.
R LimbUniversity of Michigan, Ann Arbor, MI, United States.
E C SomersDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI, United States.
V RomeroDepartment of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Michigan State University, College of Human Medicine, Grand Rapids, MI, United States.
E MozurkewichDepartment of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, University of New Mexico, Albuquerque, NM, United States.
University of Michigan–Ann Arbor · USUniversity of New Mexico · US

Funding

Immune dysfunction associated with early life heavy metal exposureK01ES019909 · NIEHS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SOMERS, EMILY CATHERINE · 2011 to 2015
$670k
NIEHS NIH HHS K01 ES019909
6 · The paper itself

Abstract

backgroundLong-term follow-up was completed in 84 mother-infant pairs of 118 women who completed a randomized controlled trial of prenatal supplementation with EPA- or DHA-rich fish oil or soy oil placebo. The goal of this study was to determine whether prenatal omega-3 fatty acid supplementation protects offspring against development of early childhood allergies. METHODS AND

findingsAssessment of childhood allergic/atopic disease among offspring at age 36 months was performed by maternal interview using the National Health Interview Survey (NHIS) questions for childhood digestive allergies, wheezing, eczema or skin allergy, and respiratory allergy. Multiple logistic regressions examined the association between prenatal supplementation and childhood outcomes, adjusted for covariates. Eczema was reported in 26/84 (31%) of offspring at age 36 months, and was significantly more prevalent in the omega-3 supplementation groups vs. placebo: EPA 13/31 (41.9%); DHA 10/26 (38.5%); placebo 3/27 (11.1%), p=0.019. Compared to placebo, EPA and DHA were associated with ≥5 times risk of offspring eczema [odds ratios (ORs): EPA 5.8 (95% CI 1.4-23.3); DHA 5.0 (95% CI 1.2-21.0)]. After adjusting for other potential risk factors (race, birth weight, vaginal/Cesarean delivery, and maternal eczema) the magnitudes of association for omega-3 supplementation increased: EPA OR 8.1 (95% CI 1.4-45.6); DHA OR 9.6 (95% CI 1.6-58.5). Maternal eczema was also significantly associated with offspring eczema in the adjusted model: OR 10.8 (95% CI 2.1-54.3).

conclusionContrary to our hypothesis, acids supplementation compared to soy oil was associated with a substantial increase in risk of childhood eczema. This association was not observed on childhood respiratory or digestive outcomes. It is unclear if these findings were driven by unfavorable effects of omega-3s, or whether there may have been unanticipated protective effects of the soy-based placebo with regards to eczema.

Indexed as

Allergic diseasesFatty acidsHypothesis

Identifiers

PMID28649675
PMCPMC5479638
OpenAlexW2533549441

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.