ArticleNPJ microgravity2017
Latent virus reactivation in astronauts on the international space station.
Article in NPJ microgravity, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 98 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
98 citing papers in PubMed, 182 citations in OpenAlex.
- Women in space: A review of known physiological adaptations and health perspectives.Experimental physiology · 2026Review
- Ophthalmic and Visual System Changes in Human Spaceflight: A Review of Mechanisms, Measurement, and Countermeasures.Journal of clinical medicine · 2026Review
- AstroOphthalmology: ocular anterior segment.NPJ microgravity · 2026Review
- Reactivation and Management of Endogenous Latent Herpesviruses in the Spaceflight Environment.Current microbiology · 2026Review
- MAPK/PMK-1 innate immune signaling protects the nematode Caenorhabditis elegans from increased intestinal colonization in an animal host-pathogen model in space.NPJ microgravity · 2026Article
- The case for space as a model of accelerated aging.Nature aging · 2026Review
- Modeling the risk of airborne transmission of respiratory viruses in microgravity.NPJ microgravity · 2026Article
- Reduced gravity and muon flux absence affectMicrobiology spectrum · 2026Article
- Astroimmunology: the effects of spaceflight and its associated stressors on the immune system.Nature reviews. Immunology · 2026Review
- Fluid shifts are main drivers for microgravity simulation-induced immune-physiological changes: findings from the VIVALDI studies.NPJ microgravity · 2026Article
- Cosmic silence and viral noise: transcriptomic crosstalk inFrontiers in microbiology · 2026Article
- Spaceflight and Medical Microbiology: Possible Implications for Standard Infection Diagnostics and Therapy.Life (Basel, Switzerland) · 2025Article
- Physical Activity Guidelines for Astronauts: An Immunological Perspective.Biomolecules · 2025Review
- [Potential biological mechanisms underlying spaceflight-induced depression symptoms in astronauts].Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2025Review
- Tear Film and Keratitis in Space: Fluid Dynamics and Nanomedicine Strategies for Ocular Protection in Microgravity.Pharmaceutics · 2025Review
- Risk of Permanent Corneal Injury in Microgravity: Spaceflight-Associated Hazards, Challenges to Vision Restoration, and Role of Biotechnology in Long-Term Planetary Missions.Life (Basel, Switzerland) · 2025Review
- Article
- Unveiling the impact of simulated microgravity on HSV-1 infection, neuroinflammation, and endogenous retroviral activation in SH-SY5Y cells.Journal of neurovirology · 2025Article
- Reactivation of latent human intracellular infections during a months-long expedition at the Antarctic Vostok station.Scientific reports · 2025Article
- Hazards of lunar surface exploration: determining the immunogenicity/allergenicity of lunar dust.Frontiers in immunology · 2025Article
38 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Reactivation of latent herpes viruses was measured in 23 astronauts (18 male and 5 female) before, during, and after long-duration (up to 180 days) spaceflight onboard the international space station . Twenty age-matched and sex-matched healthy ground-based subjects were included as a control group. Blood, urine, and saliva samples were collected before, during, and after spaceflight. Saliva was analyzed for Epstein-Barr virus, varicella-zoster virus, and herpes simplex virus type 1. Urine was analyzed for cytomegalovirus. One astronaut did not shed any targeted virus in samples collected during the three mission phases. Shedding of Epstein-Barr virus, varicella-zoster virus, and cytomegalovirus was detected in 8 of the 23 astronauts. These viruses reactivated independently of each other. Reactivation of Epstein-Barr virus, varicella-zoster virus, and cytomegalovirus increased in frequency, duration, and amplitude (viral copy numbers) when compared to short duration (10 to 16 days) space shuttle missions. No evidence of reactivation of herpes simplex virus type 1, herpes simplex virus type 2, or human herpes virus 6 was found. The mean diurnal trajectory of salivary cortisol changed significantly during flight as compared to before flight (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.