Evidence map›Paper›PMID 28649562›Full record

ArticleFrontiers in pediatrics2017

Umbilical Cord Blood NOS1 as a Potential Biomarker of Neonatal Encephalopathy.

Jun Lei, Cristina Paules, Elisabeth Nigrini, Jason M Rosenzweig, Rudhab Bahabry, Azadeh Farzin, Samuel Yang, Frances J Northington, Daniel Oros, Stephanie McKenney and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pediatrics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact, top 94% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 0 citations in OpenAlex.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Jun LeiIntegrated Research Center for Fetal Medicine, Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Cristina PaulesAragón Health Research Institute, SAMID Network ref RD12/0026/001, Zaragoza, Spain.
Elisabeth NigriniIntegrated Research Center for Fetal Medicine, Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Jason M RosenzweigIntegrated Research Center for Fetal Medicine, Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Rudhab BahabryIntegrated Research Center for Fetal Medicine, Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Azadeh FarzinDepartment of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Samuel YangDepartment of Emergency Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Frances J NorthingtonIntegrated Research Center for Fetal Medicine, Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Daniel OrosAragón Health Research Institute, SAMID Network ref RD12/0026/001, Zaragoza, Spain.
Stephanie McKenneyIntegrated Research Center for Fetal Medicine, Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Michael V JohnstonNeurosciences Intensive Care Nursery Program, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Ernest M GrahamIntegrated Research Center for Fetal Medicine, Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Irina BurdIntegrated Research Center for Fetal Medicine, Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Johns Hopkins University · USJohns Hopkins Medicine · USInstituto de Investigación Sanitaria Aragón · ES

Funding

Translational Neuroscience CoreU54HD079123 · NICHD · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI FATEMI, S. ALI, SCHLAGGAR, BRADLEY L · 2014 to 2019
$7.9M
NEUROTRANSMITTER INJURY MECHANISMS IN DEVELOPING BRAINR01NS028208 · NINDS · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI JOHNSTON, MICHAEL VAN DOREN · 1990 to 2011
$3.4M
Adult Biomarkers in Neonatal Brain Injury and DevelopmentR01HD086058 · NICHD · JOHNS HOPKINS UNIVERSITY · PI EVERETT, ALLEN D, NORTHINGTON, FRANCES J · 2016 to 2020
$3.1M
Mechanisms of Hypothermic Neuroprotection in NeonatesR01HD070996 · NICHD · JOHNS HOPKINS UNIVERSITY · PI NORTHINGTON, FRANCES J · 2012 to 2016
$1.7M
IL-1beta regulation of perinatal brain injuryK08HD073315 · NICHD · JOHNS HOPKINS UNIVERSITY · PI BURD, IRINA · 2012 to 2016
$684k
NICHD NIH HHS K08 HD073315NICHD NIH HHS R01 HD070996NICHD NIH HHS R01 HD086058NICHD NIH HHS U54 HD079123NINDS NIH HHS R01 NS028208
6 · The paper itself

Abstract

backgroundThere are no definitive markers to aid in diagnosis of neonatal encephalopathy (NE). The purpose of our study was (1) to identify and evaluate the utility of neuronal nitric oxide synthase (NOS1) in umbilical cord blood as a NE biomarker and (2) to identify the source of NOS1 in umbilical cord blood.

methodsThis was a nested case-control study of neonates >35 weeks of gestation. ELISA for NOS1 in umbilical cord blood was performed. Sources of NOS1 in umbilical cord were investigated by immunohistochemistry, western blot, ELISA, and quantitative PCR. Furthermore, umbilical cords of full-term neonates were subjected to 1% hypoxia

resultsNOS1 was present in umbilical cord blood and increased in NE cases compared with controls. NOS1 was expressed in endothelial cells of the umbilical cord vein, but not in artery or blood cells. In

conclusionThis is the first study to investigate an early marker of NE. NOS1 is elevated with hypoxia, and further studies are needed to investigate it as a valuable tool for early diagnosis of neonatal brain injury.

Indexed as

biomarkersdiagnosisneonatal encephalopathyNOS1umbilical veins

Identifiers

PMID28649562
PMCPMC5466059
OpenAlexW2621120992

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.