ArticleNeuroImage. Clinical2017
Frequency-dependent changes in local intrinsic oscillations in chronic primary insomnia: A study of the amplitude of low-frequency fluctuations in the resting state.
Article in NeuroImage. Clinical, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 5 of them syntheses that pooled it.
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Who cites it
64 citing papers in PubMed, 5 syntheses or guidelines pooled it, 101 citations in OpenAlex.
- Structural rather than functional brain alterations that characterize the differences between major depressive disorder and primary insomnia: a comparative meta-analysis.BMC medicine · 2025Pooled it
- Comparison of resting-state brain activity between insomnia and generalized anxiety disorder: A coordinate-based meta-analysis.Brain imaging and behavior · 2025Pooled it
- Effect-size seed-based d mapping of resting-state fMRI for persistent insomnia disorder.Sleep & breathing = Schlaf & Atmung · 2020Pooled it
- Pooled it
- A lack of consistent brain alterations in insomnia disorder: An activation likelihood estimation meta-analysis.Sleep medicine reviews · 2018Pooled it
- Altered Effective Connectivity of Precuneus Subregions and Associated Gene Profiles in Chronic Insomnia Disorder Patients Before and After Treatment.Brain and behavior · 2026Trial
- Intoxication due to Δ9-tetrahydrocannabinol is characterized by disrupted prefrontal cortex activity.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Trial
- Effectiveness and cerebral responses of multi-points acupuncture for primary insomnia: a preliminary randomized clinical trial and fMRI study.BMC complementary medicine and therapies · 2020Trial
- Compressing the lumbar nerve root changes the frequency-associated cerebral amplitude of fluctuations in patients with low back/leg pain.Scientific reports · 2019Trial
- Task-induced hyperfunction of the left dorsolateral prefrontal cortex in patients with primary insomnia: a near-infrared spectroscopy study during a verbal fluency task.Frontiers in psychiatry · 2026Article
- Functional connectivity across multi-frequency bands in patients with tension-type headache: a resting-state fMRI retrospective study.BMC medical imaging · 2025Article
- Effects of acute sleep deprivation on the brain function of individuals with migraine: a resting-state functional magnetic resonance imaging study.The journal of headache and pain · 2025Article
- Disrupted topological organization of brain connectome in patients with chronic low back related leg pain and clinical correlations.Scientific reports · 2025Article
- Structural and functional alterations in postmenopausal women with insomnia: an MRI study of Eight-Section Vajra Exercise intervention effects.Frontiers in neuroscience · 2025Article
- Fractional Amplitude of Low-Frequency Fluctuations and Regional Homogeneity Analyses Revealed Altered Local Spontaneous Neural Activities in Ankylosing Spondylitis.Journal of pain research · 2025Article
- Improvements in Sleep Quality in Patients With Major Depressive and Generalized Anxiety Disorders Treated With Individualized, Parcel-Guided Transcranial Magnetic Stimulation.Brain and behavior · 2024Article
- Increased functional connectivity within the salience network in patients with insomnia.Sleep & breathing = Schlaf & Atmung · 2024Article
- Sex-specific grey matter abnormalities in individuals with chronic insomnia.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Article
- Sex differences of neural connectivity in internet gaming disorder and its association with sleep quality: an exploratory fMRI study.Frontiers in psychiatry · 2024Article
- Insomnia-related brain functional correlates in first-episode drug-naïve major depressive disorder revealed by resting-state fMRI.Frontiers in neuroscience · 2024Article
4 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
New neuroimaging techniques have led to significant advancements in our understanding of cerebral mechanisms of primary insomnia. However, the neuronal low-frequency oscillation remains largely uncharacterized in chronic primary insomnia (CPI). In this study, the amplitude of low-frequency fluctuation (ALFF), a data-driven method based on resting-state functional MRI, was used to examine local intrinsic activity in 27 patients with CPI and 27 age-, sex-, and education-matched healthy controls. We examined neural activity in two frequency bands, slow-4 (between 0.027 and 0.073 Hz) and slow-5 (0.010-0.027 Hz), because blood-oxygen level dependent (BOLD) fluctuations in different low-frequency bands may present different neurophysiological manifestations that pertain to a spatiotemporal organization. The ALFF associated with the primary disease effect was widely distributed in the cerebellum posterior lobe (CPL), dorsal and ventral prefrontal cortex, anterior cingulate cortex, precuneus, somatosensory cortex, and several default-mode sub-regions. Several brain regions (i.e., the right cerebellum, anterior lobe, and left putamen) exhibited an interaction between the frequency band and patient group. In the slow-5 band, increased ALFF of the right postcentral gyrus/inferior parietal lobule (PoCG/IPL) was enhanced in association with the sleep quality (ρ = 0.414,
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.