ArticleNPJ systems biology and applications2017
A multiscale model of early cell lineage specification including cell division.
Article in NPJ systems biology and applications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Live imaging endogenous transcription factor dynamics reveals mechanisms of epiblast and primitive endoderm fate segregation.Current biology : CB · 2025Article
- Uncovering candidate Nanog-Helper genes in early mouse embryo differentiation using differential entropy and network inference.Scientific reports · 2025Article
- Single-cell analysis of bidirectional reprogramming between early embryonic states identify mechanisms of differential lineage plasticities in mice.Developmental cell · 2025Article
- AI-powered simulation-based inference of a genuinely spatial-stochastic gene regulation model of early mouse embryogenesis.PLoS computational biology · 2024Article
- Cell fate decision by a morphogen-transcription factor-chromatin modifier axis.Nature communications · 2024Article
- A geometrical model of cell fate specification in the mouse blastocyst.Development (Cambridge, England) · 2024Article
- Computational insights in cell physiology.Frontiers in systems biology · 2024Review
- The salt-and-pepper pattern in mouse blastocysts is compatible with signaling beyond the nearest neighbors.iScience · 2023Article
- Adjusting the range of cell-cell communication enables fine-tuning of cell fate patterns from checkerboard to engulfing.Journal of mathematical biology · 2023Article
- Collective behavior and self-organization in neural rosette morphogenesis.Frontiers in cell and developmental biology · 2023Review
- Journey of the mouse primitive endoderm: from specification to maturation.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Review
- Initial source of heterogeneity in a model for cell fate decision in the early mammalian embryo.Interface focus · 2022Article
- A multiscale model via single-cell transcriptomics reveals robust patterning mechanisms during early mammalian embryo development.PLoS computational biology · 2021Article
- Cell fate clusters in ICM organoids arise from cell fate heredity and division: a modelling approach.Scientific reports · 2020Article
- Live Visualization of ERK Activity in the Mouse Blastocyst Reveals Lineage-Specific Signaling Dynamics.Developmental cell · 2020Article
- Coordination between patterning and morphogenesis ensures robustness during mouse development.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Review
- Article
- Inflammation and tissue homeostasis: the NF-κB system in physiology and malignant progression.Molecular biology reports · 2020Review
- The transition from local to global patterns governs the differentiation of mouse blastocysts.PloS one · 2020Article
- A multiscale mathematical model of cell dynamics during neurogenesis in the mouse cerebral cortex.BMC bioinformatics · 2019Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Embryonic development is a self-organised process during which cells divide, interact, change fate according to a complex gene regulatory network and organise themselves in a three-dimensional space. Here, we model this complex dynamic phenomenon in the context of the acquisition of epiblast and primitive endoderm identities within the inner cell mass of the preimplantation embryo in the mouse. The multiscale model describes cell division and interactions between cells, as well as biochemical reactions inside each individual cell and in the extracellular matrix. The computational results first confirm that the previously proposed mechanism by which extra-cellular signalling allows cells to select the appropriate fate in a tristable regulatory network is robust when considering a realistic framework involving cell division and three-dimensional interactions. The simulations recapitulate a variety of
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.