Evidence map›Paper›PMID 28649434›Full record

ArticleNPJ systems biology and applications2017

A Clb/Cdk1-mediated regulation of Fkh2 synchronizes

Christian Linke, Anastasia Chasapi, Alberto González-Novo, Istabrak Al Sawad, Silvia Tognetti, Edda Klipp, Mart Loog, Sylvia Krobitsch, Francesc Posas, Ioannis Xenarios and 1 more

Open access · goldAbstract read
In one paragraph

Article in NPJ systems biology and applications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 29 citations in OpenAlex.

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  5. Unveiling Forkhead-mediated regulation of yeast cell cycle and metabolic networks.Computational and structural biotechnology journal · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 5 countries.

Christian Linke *Synthetic Systems Biology and Nuclear Organization, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, 1098 XH The Netherlands.
Anastasia ChasapiVital-IT group, Swiss Institute of Bioinformatics, University of Lausanne, CH-1015 Lausanne, Switzerland.
Alberto González-NovoCell Signaling Unit, Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, 08003 Spain.
Istabrak Al SawadSynthetic Systems Biology and Nuclear Organization, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, 1098 XH The Netherlands.
Silvia TognettiCell Signaling Unit, Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, 08003 Spain.
Edda KlippInstitute for Biology, Theoretical Biophysics, Humboldt University Berlin, Berlin, 10115 Germany.
Mart LoogInstitute of Technology, University of Tartu, Tartu, 50411 Estonia.
Sylvia KrobitschMax Planck Institute for Molecular Genetics, Berlin, 14195 Germany.
Francesc PosasCell Signaling Unit, Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, 08003 Spain.
Ioannis XenariosVital-IT group, Swiss Institute of Bioinformatics, University of Lausanne, CH-1015 Lausanne, Switzerland.
Matteo Barberis *Synthetic Systems Biology and Nuclear Organization, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, 1098 XH The Netherlands.
Pompeu Fabra University · ESMax Planck Institute for Molecular Genetics · DEUniversity of Amsterdam · NLHumboldt-Universität zu Berlin · DESIB Swiss Institute of Bioinformatics · CHUniversity of Lausanne · CHUniversity of Tartu · EE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Precise timing of cell division is achieved by coupling waves of cyclin-dependent kinase (Cdk) activity with a transcriptional oscillator throughout cell cycle progression. Although details of transcription of cyclin genes are known, it is unclear which is the transcriptional cascade that modulates their expression in a timely fashion. Here, we demonstrate that a Clb/Cdk1-mediated regulation of the Fkh2 transcription factor synchronizes the temporal mitotic

Identifiers

PMID28649434
PMCPMC5460246
OpenAlexW2594881934

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.