ArticleThe World Allergy Organization journal2017
Randomised controlled trial of a baked egg intervention in young children allergic to raw egg but not baked egg.
Article in The World Allergy Organization journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 29 citations in OpenAlex.
- Partial Egg Consumption Modifies the Diagnostic Performance of Allergy Tests to Predict Outcome of Double-Blind Placebo-Controlled Food Challenges to Egg.The journal of allergy and clinical immunology. In practice · 2024Trial
- Multiscale Structural Remodeling of Oleosins by Thermal Processing: Mechanisms and Implications for Allergenicity Modulation in Oilseed Crops.Comprehensive reviews in food science and food safety · 2026Review
- Oral Food Challenges to Milk and Egg in Children: Associations with Skin Prick Tests and IgE Sensitization Profiles.Nutrients · 2026Article
- Egg desensitization is achieved effectively and safely through a low maintenance dose protocol.The journal of allergy and clinical immunology. Global · 2025Article
- Effects of Food Processing on Allergenicity.Current allergy and asthma reports · 2025Review
- Hen's egg ladder: Therapy option for the gradual introduction of hen's eggs in cases of hen's egg allergy.Allergologie select · 2024Review
- Tolerance to heated egg in egg allergy: Explanations and implications for prevention and treatment.Clinical and translational allergy · 2023Review
- Allergen immunotherapy for food allergy: Evidence and outlook.Allergologie select · 2022Review
- Adult onset egg allergy: a case report.Clinical and molecular allergy : CMA · 2021Article
- Constraint-induced aphasia therapy for patients with aphasia: A systematic review.International journal of nursing sciences · 2020Review
- Daily baked egg intake may accelerate the development of tolerance to raw egg in egg-allergic children.European journal of pediatrics · 2020Article
- Review
- The Impact of Baked Egg and Baked Milk Diets on IgE- and Non-IgE-Mediated Allergy.Clinical reviews in allergy & immunology · 2018Review
- Debates in Allergy Medicine: Oral immunotherapy shortens the duration of milk and egg allergy - the con argument.The World Allergy Organization journal · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundConsumption of baked egg by raw egg allergic children is associated with immune changes suggesting development of tolerance. However, causation has not been tested using a double blind randomized controlled trial (RCT). We aimed to compare clinical and immunological outcomes after baked egg (BE) consumption in young BE tolerant egg allergic children.
methodsIn a double blind RCT, BE tolerant egg allergic children consumed 10 g BE (1.3 g protein) 2 to 3 times per week for 6 months (
resultsAfter the intervention there was no difference in raw egg tolerance between groups, (23.5% (4/17) intervention group and 33.3% (6/18) control group). This was independent of age and amount of BE consumed (aOR 0.50 CI 0.11-2.40 DISCUSSION: We conducted this trial because inclusion of baked egg protein in the diet of egg allergic children appears to move children towards a more tolerant immune profile. Strengths of our study include design of the blinded intervention, the consistent dosing protocol and the regular monitoring of symptoms and intake. However, the study was limited by small sample size resulting in insufficient power to show statistically significant results.
conclusionOur study suggests that short term, regular consumption of BE by BE tolerant 1 to 5 year old children with IgE mediated raw egg allergy may not induce, accelerate or slow development of tolerance to raw egg in this selected population. Trials with larger sample sizes are required to further test this hypothesis.
trial registrationThe trial was registered on 7
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.