Evidence map›Paper›PMID 28649086›Full record

ArticleJournal of the American Heart Association2017

Early Life Risk Factors for Incident Atrial Fibrillation in the Helsinki Birth Cohort Study.

Linda S B Johnson, Minna Salonen, Eero Kajantie, David Conen, Jeff S Healey, Clive Osmond, Johan G Eriksson

Open access · goldAbstract read
In one paragraph

Article in Journal of the American Heart Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
4.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 6 institutions in 4 countries.

Linda S B JohnsonDepartment of Clinical Sciences, Lund University Skåne University Hospital, Malmö, Sweden linda.johnson@med.lu.se.
Minna SalonenFolkhälsan Research Center, Helsinki, Finland.
Eero KajantieDepartment of Chronic Disease Prevention, National Institute of Health and Welfare, Helsinki, Finland.
David ConenPopulation Health Research Institute, McMaster University, Hamilton, Ontario, Canada.
Jeff S HealeyPopulation Health Research Institute, McMaster University, Hamilton, Ontario, Canada.
Clive OsmondMedical Research Council Lifecourse Epidemiology Unit, University of Southampton, United Kingdom.
Johan G ErikssonFolkhälsan Research Center, Helsinki, Finland.
McMaster University · CAFinnish Institute for Health and Welfare · FIHelsinki University Hospital · FILund University · SEUniversity of Helsinki · FIUniversity of Southampton · GB

Funding

Medical Research Council MC_U147574242Medical Research Council MC_UP_A620_1016Medical Research Council MC_UU_12011/3Medical Research Council MC_UU_12011/4
6 · The paper itself

Abstract

backgroundEarly life risk factors are associated with cardiometabolic disease, but have not been fully studied in atrial fibrillation (AF). There are discordant results from existing studies of birth weight and AF, and the impact of maternal body size, gestational age, placental size, and birth length is unknown. METHODS AND

resultsThe Helsinki Birth Cohort Study includes 13 345 people born as singletons in Helsinki in the years 1934-1944. Follow-up was through national registries, and ended on December 31, 2013, with 907 incident cases. Cox regression analyses stratified on year of birth were constructed for perinatal variables and incident AF, adjusting for offspring sex, gestational age, and socioeconomic status at birth. There was a significant U-shaped association between birth weight and AF (

conclusionsHigh maternal body mass index during pregnancy and maternal height are previously undescribed predictors of offspring AF. Efforts to prevent maternal obesity might reduce later AF in offspring. Birth weight has a U-shaped relation to incident AF independent of other perinatal variables.

Indexed as

MothersPrenatal Exposure Delayed EffectsAgedAge FactorsAtrial FibrillationBody HeightBody Mass IndexBody WeightFemaleFinlandFollow-Up StudiesHumansIncidenceMaleMiddle AgedObesityatrial fibrillationhypertensionpopulation sciencepopulation studiesrisk prediction

Identifiers

PMID28649086
PMCPMC5669198
OpenAlexW2681022005

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.