ArticleHeart rhythm2017
Simultaneous recordings of intrinsic cardiac nerve activity and skin sympathetic nerve activity from human patients during the postoperative period.
Article in Heart rhythm, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03243448 (Using Skin Sympathetic Nerve Activity to Estimate Sympathetic Tone in Human), which is not on this map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Using Skin Sympathetic Nerve Activity to Estimate Sympathetic Tone in Human
Who cites it
8 citing papers in PubMed, 23 citations in OpenAlex.
- Sympathetic toggled paroxysmal atrial fibrillation and recurrent premature atrial contractions in ambulatory patients.Heart rhythm · 2024Article
- Autonomic Modulation of Atrial Fibrillation.JACC. Basic to translational science · 2023Review
- The cardiac autonomic nervous system: an introduction.Herzschrittmachertherapie & Elektrophysiologie · 2021Review
- Skin Sympathetic Nerve Activity and the Short-Term QT Interval Variability in Patients With Electrical Storm.Frontiers in physiology · 2021Article
- Atrial Myopathy.JACC. Basic to translational science · 2019Review
- Postoperative atrial fibrillation: mechanisms, manifestations and management.Nature reviews. Cardiology · 2019Review
- Cardiac Sympathetic Afferent Denervation Protects Against Ventricular Arrhythmias by Modulating Cardiac Sympathetic Nerve Activity During Acute Myocardial Infarction.Medical science monitor : international medical journal of experimental and clinical research · 2019Article
- Ganglionated plexi as neuromodulation targets for atrial fibrillation.Journal of cardiovascular electrophysiology · 2017Review
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Authors and funding
12 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundIntrinsic cardiac nerve activity (ICNA) and skin nerve activity (SKNA) are both associated with cardiac arrhythmias in dogs.
objectiveThe purpose of this study was to test the hypothesis that ICNA and SKNA correlate with postoperative cardiac arrhythmias in humans.
methodsEleven patients (mean age 60 ± 13 years; 4 women) were enrolled in this study. Electrical signals were simultaneously recorded from electrocardiogram (ECG) patch electrodes on the chest wall and from 2 temporary pacing wires placed during open heart surgery on the left atrial epicardial fat pad. The signals were filtered to display SKNA and ICNA. Premature atrial contractions (PACs) and premature ventricular contractions were determined manually. The SKNA and ICNA of the first 300 minutes of each patient were calculated minute by minute to determine baseline average amplitudes of nerve activities and to determine their correlation with arrhythmia burden.
resultsWe processed 1365 ± 973 minutes of recording per patient. Low-amplitude SKNA and ICNA were present at all time, while the burst discharges were observed much less frequently. Both SKNA and burst ICNA were significantly associated with the onset of PACs and premature ventricular contractions. Baseline average ICNA (aICNA), but not average SKNA, had a significant association with PAC burden. The correlation coefficient (r) between aICNA and PAC burden was 0.78 (P < .01). A patient with the greatest aICNA developed postoperative atrial fibrillation.
conclusionICNA and SKNA can be recorded from human patients in the postoperative period. The baseline magnitude of ICNA correlates with PAC burden and development of postoperative atrial fibrillation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.