Evidence map›Paper›PMID 28648628›Full record

ArticleProgress in biophysics and molecular biology2017

Impact of titin strain on the cardiac slow force response.

Younss Ait-Mou, Mengjie Zhang, Jody L Martin, Marion L Greaser, Pieter P de Tombe

Abstract read
In one paragraph

Article in Progress in biophysics and molecular biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Mechanobiology in cardiac mechanics.Biophysical reviews · 2021
    Article
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Younss Ait-MouDepartment of Cell and Molecular Physiology, Loyola University Chicago, Stritch School of Medicine, 2160 South First Ave, Maywood, IL 60153, United States.
Mengjie ZhangDepartment of Cell and Molecular Physiology, Loyola University Chicago, Stritch School of Medicine, 2160 South First Ave, Maywood, IL 60153, United States.
Jody L MartinDepartment of Cell and Molecular Physiology, Loyola University Chicago, Stritch School of Medicine, 2160 South First Ave, Maywood, IL 60153, United States.
Marion L GreaserDepartment of Animal Sciences, Muscle Biology Laboratory, University of Wisconsin - Madison, 1450 Linden Drive, Madison, WI 53706, United States.
Pieter P de TombeDepartment of Cell and Molecular Physiology, Loyola University Chicago, Stritch School of Medicine, 2160 South First Ave, Maywood, IL 60153, United States. Electronic address: pdetombe@luc.edu.

Funding

Sarcomeric Modifications and Progressive Cardiac MaladaptationP01HL062426 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI DE TOMBE, PIETER P. · 2000 to 2020
$42.4M
Frank-Starling's Law of the Heart: Cellular MechanismsR01HL075494 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI DE TOMBE, PIETER P. · 2005 to 2012
$3.0M
Titin Splicing Mechanisms and Physical ImplicationsR01HL077196 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI GREASER, MARION LEWIS · 2004 to 2010
$1.9M
NHLBI NIH HHS P01 HL062426NHLBI NIH HHS R01 HL075494NHLBI NIH HHS R01 HL077196
6 · The paper itself

Abstract

Stretch of myocardium, such as occurs upon increased filling of the cardiac chamber, induces two distinct responses: an immediate increase in twitch force followed by a slower increase in twitch force that develops over the course of several minutes. The immediate response is due, in part, to modulation of myofilament Ca

Indexed as

Stress, MechanicalAnimalsBiomechanical PhenomenaConnectinMyocardiumRatsConnectinIsolated cardiac trabeculaePassive forceRatStretchTwitch force

Identifiers

PMID28648628
PMCPMC5716905

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.