Evidence map›Paper›PMID 28648609›Full record

ArticleStructure (London, England : 1993)2017

Critical Role of Water Molecules in Proton Translocation by the Membrane-Bound Transhydrogenase.

Pius S Padayatti, Josephine H Leung, Paween Mahinthichaichan, Emad Tajkhorshid, Andrii Ishchenko, Vadim Cherezov, S Michael Soltis, J Baz Jackson, C David Stout, Robert B Gennis and 1 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Structure (London, England : 1993), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Redox regulation of the immune response.Cellular & molecular immunology · 2022
    Review
  3. Ligand binding and conformational dynamics of theComputational and structural biotechnology journal · 2022
    Article
  4. Review
  5. Review
  6. Chemical tools for membrane protein structural biology.Current opinion in structural biology · 2019
    Review
  7. Article
  8. Article
  9. Purification of AdultThe Journal of parasitology · 2019
    Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 3 countries.

Pius S PadayattiDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA. Electronic address: piuspada@scripps.edu.
Josephine H LeungDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
Paween MahinthichaichanDepartment of Biochemistry, University of Illinois Urbana-Champaign, Champaign, IL 61801, USA.
Emad TajkhorshidDepartment of Biochemistry, University of Illinois Urbana-Champaign, Champaign, IL 61801, USA.
Andrii IshchenkoDepartment of Chemistry, Bridge Institute, University of Southern California, Los Angeles, CA 90089, USA.
Vadim CherezovDepartment of Chemistry, Bridge Institute, University of Southern California, Los Angeles, CA 90089, USA; Laboratory for Structural Biology of GPCRs, Moscow Institute of Physics and Technology, Dolgoprudny 141701, Russia.
S Michael SoltisStanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Menlo Park, CA 94025, USA.
J Baz JacksonSchool of Biosciences, University of Birmingham, Birmingham B15 2TT, UK.
C David StoutDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
Robert B GennisDepartment of Biochemistry, University of Illinois Urbana-Champaign, Champaign, IL 61801, USA.
Qinghai ZhangDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA. Electronic address: qinghai@scripps.edu.
Scripps Research Institute · USUniversity of Illinois Urbana-Champaign · USMoscow Institute of Physics and Technology · RUStanford Synchrotron Radiation Lightsource · USUniversity of Birmingham · GBUniversity of Southern California · US

Funding

X-ray Absorption Spectroscopy (XAS) pp.711-759P41GM103393 · NIGMS · STANFORD UNIVERSITY · PI HODGSON, KEITH O · 2012 to 2019
$30.6M
WHOLE CELL SIMULATIONP41GM104601 · NIGMS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI TAJKHORSHID, EMAD · 2012 to 2021
$19.0M
PROTEIN/LIPID INTERACTIONSR01HL016101 · NHLBI · UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN · PI GENNIS, ROBERT B · 1985 to 2015
$6.8M
High-Speed High-Sensitivity Detector for X-ray Micro-Crystallography at GM/CA@APSS10OD012289 · OD · UNIVERSITY OF CHICAGO · PI FISCHETTI, ROBERT F. · 2014 to 2014
$2.0M
Transhydrogenase: Structure, Dynamics, and MechanismR01GM103838 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI ZHANG, QINGHAI · 2014 to 2017
$1.5M
NHLBI NIH HHS R01 HL016101NIGMS NIH HHS P41 GM103393NIGMS NIH HHS P41 GM104601NIGMS NIH HHS R01 GM103838NIH HHS S10 OD012289
6 · The paper itself

Abstract

The nicotinamide nucleotide transhydrogenase (TH) is an integral membrane enzyme that uses the proton-motive force to drive hydride transfer from NADH to NADP

Indexed as

Hydrophobic and Hydrophilic InteractionsProtonsCell MembraneHydrogen-Ion ConcentrationIon Channel GatingMolecular Dynamics SimulationMutationNADNADPNADP TranshydrogenasesThermus thermophilusNADNADPNADP TranshydrogenasesProtonsmembrane proteinmolecular dynamics simulationsproton channeltranshydrogenaseX-ray crystallography

Identifiers

PMID28648609
PMCPMC5524145
OpenAlexW2669334046

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.