ArticleNeuron2017
Selective Optogenetic Control of Purkinje Cells in Monkey Cerebellum.
Article in Neuron, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
48 citing papers in PubMed, 95 citations in OpenAlex.
- Optotagging in primate cortex uncovers excitatory and inhibitory neuron specializations in form vision.Nature communications · 2026Article
- A neural language for the cerebellum: control of behavior via competing populations of Purkinje cells.Journal of neurophysiology · 2026Review
- Optogenetic Manipulation of Covert Attention in the Nonhuman Primate.Journal of cognitive neuroscience · 2025Article
- Comparative Analysis of Six Adeno-Associated Viral Vector Serotypes in Mouse Inferior Colliculus and Cerebellum.eNeuro · 2024Article
- Comparative analysis of six adeno-associated viral vector serotypes in mouse inferior colliculus and cerebellum.bioRxiv : the preprint server for biology · 2024Article
- Primate eye tracking with carbon-nanotube-paper-composite based capacitive sensors and machine learning algorithms.Journal of neuroscience methods · 2024Article
- Intrinsic and synaptic determinants of receptive field plasticity in Purkinje cells of the mouse cerebellum.Nature communications · 2024Article
- Climbing fibers provide essential instructive signals for associative learning.Nature neuroscience · 2024Article
- The olivary input to the cerebellum dissociates sensory events from movement plans.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Closed-Loop Optogenetic Perturbation of Macaque Oculomotor Cerebellum: Evidence for an Internal Saccade Model.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Complex spikes perturb movements and reveal the sensorimotor map of Purkinje cells.Current biology : CB · 2023Article
- Genetic Approaches for Neural Circuits Dissection in Non-human Primates.Neuroscience bulletin · 2023Review
- A mosaic adeno-associated virus vector as a versatile tool that exhibits high levels of transgene expression and neuron specificity in primate brain.Nature communications · 2023Article
- Behavioral detectability of optogenetic stimulation of inferior temporal cortex varies with the size of concurrently viewed objects.Current research in neurobiology · 2023Article
- Behavioral optogenetics in nonhuman primates; a psychological perspective.Current research in neurobiology · 2023Review
- Effect of induced diabetes on morphometric indexes of the cerebellar cortex and gene expression in C57BL mice.Iranian journal of basic medical sciences · 2023Article
- Advances in AAV technology for delivering genetically encoded cargo to the nonhuman primate nervous system.Current research in neurobiology · 2023Review
- Optogenetics in primate cortical networks.Frontiers in neuroanatomy · 2023Article
- Capacitive Eye Tracker Made of Fractured Carbon Nanotube-Paper Composites for Wearable Applications.Sensors and actuators. A, Physical · 2022Article
- Applications of chemogenetics in non-human primates.Current opinion in pharmacology · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Purkinje cells of the primate cerebellum play critical but poorly understood roles in the execution of coordinated, accurate movements. Elucidating these roles has been hampered by a lack of techniques for manipulating spiking activity in these cells selectively-a problem common to most cell types in non-transgenic animals. To overcome this obstacle, we constructed AAV vectors carrying the channelrhodopsin-2 (ChR2) gene under the control of a 1 kb L7/Pcp2 promoter. We injected these vectors into the cerebellar cortex of rhesus macaques and tested vector efficacy in three ways. Immunohistochemical analyses confirmed selective ChR2 expression in Purkinje cells. Neurophysiological recordings confirmed robust optogenetic activation. Optical stimulation of the oculomotor vermis caused saccade dysmetria. Our results demonstrate the utility of AAV-L7-ChR2 for revealing the contributions of Purkinje cells to circuit function and behavior, and they attest to the feasibility of promoter-based, targeted, genetic manipulations in primates.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.