ArticleBioorganic & medicinal chemistry2017
Isolation, structure elucidation, and synthesis of antiplasmodial quinolones from Crinum firmifolium.
Article in Bioorganic & medicinal chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Quinolinone and Amicoumacin Derivatives From the Deep Sea-Derived Bacillus rugosus SCSIO 41395 and Their Bacteriostatic Activities Against Pseudomonas aeruginosa.Chemistry & biodiversity · 2026Article
- The Phytochemistry and Pharmacology ofMolecules (Basel, Switzerland) · 2022Review
- Antimalarial Natural Products.Progress in the chemistry of organic natural products · 2022Article
- Bacterial Alkyl-4-quinolones: Discovery, Structural Diversity and Biological Properties.Molecules (Basel, Switzerland) · 2020Review
- Galtonosides A-E: Antiproliferative and Antiplasmodial Cholestane Glycosides fromJournal of natural products · 2020Article
- Anibamine and Its Analogues: Potent Antiplasmodial Agents fromJournal of natural products · 2020Article
- Antiplasmodial natural products: an update.Malaria journal · 2019Review
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Antiplasmodial bioassay guided fractionation of a Madagascar collection of Crinum firmifolium led to the isolation of seven compounds. Five of the seven compounds were determined to be 2-alkylquinolin-4(1H)-ones with varying side chains. Compounds 1 and 4 were determined to be known compounds with reported antiplasmodial activities, while 5 was believed to be a new branched 2-alkylquinolin-4(1H)-one, however, it was isolated in limited quantities and in admixture and therefore was synthesized to confirm its structure as a new antiplasmodial compound. Along with 5, two other new and branched compounds 6 and 7 were synthesized as well. Accompanying the five quinolones were two known compounds 2 and 3 which are inactive against Plasmodium falciparum. The isolation, structure elucidation, total synthesis, and biological evaluation of these compounds are discussed in this article.
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