ArticleAmerican journal of kidney diseases : the official journal of the National Kidney Foundation2017
Associations of Early Kidney Disease With Brain Magnetic Resonance Imaging and Cognitive Function in African Americans With Type 2 Diabetes Mellitus.
Article in American journal of kidney diseases : the official journal of the National Kidney Foundation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- Cognitive protection of incretin-based therapies in patients with type 2 diabetes mellitus: A systematic review and meta-analysis based on clinical studies.Journal of diabetes investigation · 2023Pooled it
- Relationship Between Type 2 Diabetes and White Matter Hyperintensity: A Systematic Review.Frontiers in endocrinology · 2020Pooled it
- Association between cerebral lesions and the severity of diabetic cardiovascular disease, retinopathy, and nephropathy-new lessons to learn from neuroimaging.Journal of endocrinological investigation · 2025Review
- Metabolomic signatures of cognitive function in a type 2 Diabetes-Enriched cohort.Scientific reports · 2025Article
- Cognitive impairment in chronic kidney disease: role of brain imaging, functional imaging, electroencephalography, cerebrospinal fluid biomarkers and sensors.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2025Review
- Neurocognitive Profile in Pediatric Kidney Transplant Candidates: Effects of Medical and Sociodemographic Factors.Research square · 2024Article
- Associations between renal function, hippocampal volume, and cognitive impairment in 544 outpatients.Frontiers in neurology · 2024Article
- Association of Kidney Function Measures With Signs of Neurodegeneration and Small Vessel Disease on Brain Magnetic Resonance Imaging: The Atherosclerosis Risk in Communities (ARIC) Study.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2023Article
- CKD, Brain Atrophy, and White Matter Lesion Volume: The Japan Prospective Studies Collaboration for Aging and Dementia.Kidney medicine · 2023Article
- Rapid-onset dystonia-parkinsonism is associated with reduced cerebral blood flow without gray matter changes.Frontiers in neurology · 2023Article
- Albuminuria, cognition, and MRI biomarkers of cerebrovascular disease in American Indians of the Zuni Pueblo.eNeurologicalSci · 2022Article
- Albuminuria as a risk factor for mild cognitive impairment and dementia-what is the evidence?Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2021Review
- Vascular complications of diabetes: natural history and corresponding risks of dementia in a national cohort of adults with diabetes.Acta diabetologica · 2021Article
- Diabetes, Albuminuria and the Kidney-Brain Axis.Journal of clinical medicine · 2021Review
- Review of the structural and functional brain changes associated with chronic kidney disease.Physiological research · 2020Review
- White Matter Microstructure Changes and Cognitive Impairment in the Progression of Chronic Kidney Disease.Frontiers in neuroscience · 2020Article
- Association of sickle cell trait with measures of cognitive function and dementia in African Americans.eNeurologicalSci · 2019Article
- HIV disease and diabetes interact to affect brain white matter hyperintensities and cognition.AIDS (London, England) · 2018Article
- Prevalence and Risk of Severe Cognitive Impairment in Advanced Chronic Kidney Disease.The journals of gerontology. Series A, Biological sciences and medical sciences · 2018Article
- Metabolic Biomarkers of Aging and Aging-related Diseases in Chinese Middle-Aged and Elderly Men.The journal of nutrition, health & aging · 2018Article
Corrections and comments
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Authors and funding
21 authors at 8 institutions in 1 country.
Funding
Abstract
backgroundRelationships between early kidney disease, neurocognitive function, and brain anatomy are poorly defined in African Americans with type 2 diabetes mellitus (T2DM). STUDY
designCross-sectional associations were assessed between cerebral anatomy and cognitive performance with estimated glomerular filtration rate (eGFR) and urine albumin-creatinine ratio (UACR) in African Americans with T2DM. SETTING &
participantsAfrican Americans with cognitive testing and cerebral magnetic resonance imaging (MRI) in the African American-Diabetes Heart Study Memory in Diabetes (AA-DHS MIND; n=512; 480 with MRI) and Action to Control Cardiovascular Risk in Diabetes (ACCORD) MIND (n=484; 104 with MRI) studies. PREDICTORS: eGFR (CKD-EPI creatinine equation), spot UACR. MEASUREMENTS: MRI-based cerebral white matter volume (WMV), gray matter volume (GMV), and white matter lesion volume; cognitive performance (Mini-Mental State Examination, Digit Symbol Coding, Stroop Test, and Rey Auditory Verbal Learning Test). Multivariable models adjusted for age, sex, body mass index, scanner, intracranial volume, education, diabetes duration, hemoglobin A
resultsMean participant age was 60.1±7.9 (SD) years; diabetes duration, 12.1±7.7 years; hemoglobin A LIMITATIONS: Cross-sectional; single UACR measurement.
conclusionsIn African Americans with T2DM, mildly high UACR and mildly low eGFR were associated with smaller GMV and increased white matter lesion volume. UACR was associated with poorer processing speed and working memory.
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