Evidence map›Paper›PMID 28648126›Full record

ArticleRejuvenation research2018

Knee Osteoarthritis and Risk of Hypertension: A Longitudinal Cohort Study.

Nicola Veronese, Brendon Stubbs, Marco Solmi, Toby O Smith, Marianna Noale, Patricia Schofield, Stefania Maggi

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Rejuvenation research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 2 pooled it
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 60 citations in OpenAlex.

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  16. Association of Hypertension with Knee Pain Severity Among People with Knee Osteoarthritis.Pain management nursing : official journal of the American Society of Pain Management Nurses · 2022
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  19. Reduction in anxiety and depression symptoms one year after knee replacement: a register-based cohort study of 403 patients.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 5 countries.

Nicola Veronese1 National Research Council, Neuroscience Institute , Aging Branch, Padova, Italy .
Brendon Stubbs3 Physiotherapy Department, South London and Maudsley NHS Foundation Trust , London, United Kingdom .
Marco Solmi2 Geriatrics Unit, Department of Geriatric Care, OrthoGeriatrics and Rehabilitation, Ente Ospedaliero Galliera Hospital, National Relevance and High Specialization Hospital , Genova, Italy .
Toby O Smith8 Faculty of Medicine and Health Sciences, University of East Anglia , Norwich Research Park, Norwich, United Kingdom .
Marianna Noale1 National Research Council, Neuroscience Institute , Aging Branch, Padova, Italy .
Patricia Schofield5 Faculty of Health, Social Care and Education, Anglia Ruskin University , Chelmsford, United Kingdom .
Stefania Maggi1 National Research Council, Neuroscience Institute , Aging Branch, Padova, Italy .
Ente Ospedaliero Ospedali Galliera · ITNeuroscience Institute · ITAnglia Ruskin University · GBNorwich Research Park · GBSouth London and Maudsley NHS Foundation Trust · GB

Funding

Department of Health ICA-CL-2017-03-001
6 · The paper itself

Abstract

Although previous research has indicated an association between osteoarthritis (OA) and cardiovascular disease, it remains unclear whether people with OA are at greater risk of developing hypertension. The aim of this study was to answer this uncertainity. We used the data of the Osteoarthritis Initiative, an ongoing public and private longitudinal study including people at higher risk of OA or having knee OA. Knee OA was defined through radiological and clinical assessment. Incident hypertension was defined as a systolic blood pressure ≥140 mmHg and/or a diastolic value ≥90 mmHg. Multivariate Cox's regression analyses were constructed considering the presence of knee OA as the exposure and incident hypertension as the outcome during a 96-month follow-up interval. A total of 3558 people with normative blood pressure values at baseline were analyzed (1930 OA/1628 controls). Incidence of hypertension within the follow-up interval was significantly higher in people with knee OA than in those without (60/[1000 person-years] vs. 55/[1000 person-years]; p < 0.0001). After adjusting for 13 confounders, people with knee OA had a 13% higher chance of developing hypertension (hazard ratio = 1.13; 95% confidence interval: 1.01-1.26; p = 0.03). Propensity score analysis did not alter these conclusions. In conclusion, this is the first longitudinal data analysis to demonstrate that people with knee OA have a higher chance of developing hypertension than those without OA. Our data suggest that monitoring blood pressure and prescribing health promotion interventions may be warranted among people with OA to mitigate the potential onset and adverse consequences of hypertension.

Indexed as

AgedBlood PressureDiastoleFemaleFollow-Up StudiesHumansHypertensionLongitudinal StudiesMaleMiddle AgedOsteoarthritis, KneeRisk FactorsSystolecardiovascular diseaseepidemiologyhypertensionosteoarthritis

Identifiers

PMID28648126
PMCPMC5824487
OpenAlexW2775541939

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.