Evidence map›Paper›PMID 28647836›Full record

ArticleInflammation research : official journal of the European Histamine Research Society ... [et al.]2017

From medicinal plant extracts to defined chemical compounds targeting the histamine H

Annika Frank, Saleh Abu-Lafi, Azmi Adawi, Johannes S Schwed, Holger Stark, Anwar Rayan

Abstract read
PubMed Publisher
In one paragraph

Article in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.2field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 21 citations in OpenAlex.

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  8. Nature is the best source of anti-inflammatory drugs: indexing natural products for their anti-inflammatory bioactivity.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2018
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 3 countries.

Annika FrankInstitute of Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, 40225, Düsseldorf, Germany.
Saleh Abu-LafiFaculty of Pharmacy, Al-Quds University, P.O. Box 20002, Abu-Dies, Palestine.
Azmi AdawiInstitute of Applied Research, The Galilee Society, P.O. Box 437, 20200, Shefa-'Amr, Israel.
Johannes S SchwedInstitute of Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, 40225, Düsseldorf, Germany.
Holger StarkInstitute of Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, 40225, Düsseldorf, Germany. stark@hhu.de.ORCID http://orcid.org/0000-0003-3336-1710
Anwar RayanInstitute of Applied Research, The Galilee Society, P.O. Box 437, 20200, Shefa-'Amr, Israel.
Heinrich Heine University Düsseldorf · DEAl-Qasemi Academic College of Education · ILAl-Quds University · PS

Funding

Deutsche Forschungsgemeinschaft GRK2158Deutsche Forschungsgemeinschaft INST 208/664European Cooperation in Science and Technology BM0806European Cooperation in Science and Technology CA15125European Cooperation in Science and Technology CM1204
6 · The paper itself

Abstract

objectivesThe aim was to evaluate the activity of seven medicinal, anti-inflammatory plants at the hH MATERIALS: Activities were analyzed with membrane preparations from Sf9 cells, transiently expressing the hH

methodsFrom the methanolic extract of C. longa curcumin (1), demethoxycurcumin (2) and bis(4-hydroxy-cinnamoyl)methane (3) were isolated, purified with HPLC (elution-time 10.20, 9.66, 9.20 min, respectively) and together with six additional extracts, were characterized via radioligand binding studies at the hH

resultsCompounds from C. longa were the most potent ligands at the hH

conclusionWithin this study, defined compounds of C. longa were recognized as potential ligands and reasonable lead structures at the hH

Indexed as

Anti-Inflammatory Agents, Non-SteroidalBinding, CompetitiveCell LineCell MembraneCurcumaCurcuminDiarylheptanoidsDose-Response Relationship, DrugHumansPlant ExtractsPlants, MedicinalRadioligand AssayReceptors, Histamine H4Anti-Inflammatory Agents, Non-SteroidalCurcumindemethoxycurcuminDiarylheptanoidsPlant ExtractsReceptors, Histamine H4turmeric extractCurcuma longahH4RInflammatory diseasesNatural compoundsPhenylpropanoids

Identifiers

PMID28647836
OpenAlexW2662604672

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.