Evidence map›Paper›PMID 28647809›Full record

ArticleClinical research in cardiology : official journal of the German Cardiac Society2017

Left ventricles of aging athletes: better untwisters but not more relaxed during exercise.

Claire Maufrais, G Doucende, T Rupp, M Dauzat, P Obert, S Nottin, I Schuster

Abstract read
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In one paragraph

Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Left ventricular geometry and function in early repolarization: results from the population-based Gutenberg Health Study.Clinical research in cardiology : official journal of the German Cardiac Society · 2019
    Observational
  7. Review
  8. Clarification on the role of LV untwisting in LV "relaxation" and diastolic filling.Clinical research in cardiology : official journal of the German Cardiac Society · 2017
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Claire MaufraisLaboratoire de Pharm-écologie cardiovasculaire, Faculté des Sciences, LAPEC EA4278, Avignon University, 33 Rue Louis Pasteur, 84000, Avignon, France. claire.maufrais@hotmail.com.ORCID http://orcid.org/0000-0001-6530-3393
G DoucendeLaboratoire de Pharm-écologie cardiovasculaire, Faculté des Sciences, LAPEC EA4278, Avignon University, 33 Rue Louis Pasteur, 84000, Avignon, France.
T RuppLaboratory of Exercise Physiology, University of Savoie, Chambery, France.
M DauzatEA 2992, Dysfunction of Vascular Interfaces Research Laboratory, Faculty of Medicine, Montpellier I University and Nimes University Hospital Center, Nîmes, France.
P ObertLaboratoire de Pharm-écologie cardiovasculaire, Faculté des Sciences, LAPEC EA4278, Avignon University, 33 Rue Louis Pasteur, 84000, Avignon, France.
S NottinLaboratoire de Pharm-écologie cardiovasculaire, Faculté des Sciences, LAPEC EA4278, Avignon University, 33 Rue Louis Pasteur, 84000, Avignon, France.
I SchusterEA 2992, Dysfunction of Vascular Interfaces Research Laboratory, Faculty of Medicine, Montpellier I University and Nimes University Hospital Center, Nîmes, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveWith an aging population and the increasing prevalence of heart failure with preserved ejection fraction, developing strategies to prevent diastolic dysfunction is crucial. Regular endurance training has been suggested to be one such strategy. However, the underlying mechanisms of training, including the effect on left ventricular (LV) untwist, which promotes LV filling, are unclear and studies exploring the heart during exercise in the aging heart are lacking.

methodsCardiopulmonary exercise testing with speckle tracking echocardiography was realized in male subjects: 16 young athletes (YA), 19 young controls (YC), 22 middle-aged athletes (MA) with a lifelong history of endurance training, and 20 middle-aged controls (MC).

resultsDuring exercise, the early filling was lower in MC compared to YC, whereas it was preserved between YA and MA. At exercise, peak untwisting rate/peak twist ratio and the percentage of untwist during isovolumic relaxation time were decreased in senior groups but higher in YA and MA compared to age-matched controls. Early diastolic filling reserve correlated with untwisting rate/peak twist reserve in YA and MA (R

conclusionLV intrinsic relaxation was similarly lower with age, independently of training, while the age-related decrease of untwist during exercise was lower with lifelong exercise training. The preservation of untwist mechanics in MA could thus sustain the early filling during exercise. Further studies are needed to confirm the role of exercise training as a preventive strategy for diastolic dysfunction and heart failure.

Indexed as

AgingAthletesAdultAgedEchocardiography, DopplerExerciseExercise TestFemaleHeart FailureHeart VentriclesHumansMaleMiddle AgedStroke VolumeVentricular Function, LeftAgeDiastolic functionEndurance trainingExerciseSpeckle tracking echocardiography

Identifiers

PMID28647809

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.