ReviewPractical neurology2017
Revolution in acute ischaemic stroke care: a practical guide to mechanical thrombectomy.
Review in Practical neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Associations between basic physiological observations recorded pre-thrombectomy and functional outcome: a systematic review and meta-analysis.Frontiers in stroke · 2023Pooled it
- Clinical image analysis to build patient-specific models of acute ischemic stroke patients.Physical and engineering sciences in medicine · 2026Article
- Thrombus composition in ischaemic stroke: histological and radiological evaluation, and implications for acute clinical management.Journal of thrombosis and thrombolysis · 2025Review
- Prehospital video triage of suspected stroke patients in Greater Manchester: pilot project report.BMJ open quality · 2025Article
- Insight Into Uncommon Territory: Exploring Internuclear Ophthalmoplegia in Artery of Percheron Infarct.Cureus · 2024Article
- Segmenting Ischemic Penumbra and Infarct Core Simultaneously on Non-Contrast CT of Patients with Acute Ischemic Stroke Using Novel Convolutional Neural Network.Biomedicines · 2024Article
- A qualitative exploration of ambulance clinician behaviour and decision making to identify factors influencing on-scene times for suspected stroke patients in North East England.British paramedic journal · 2024Article
- Advancements in aspiration catheter tip design for thrombectomy: a comprehensive patent review.Frontiers in medical technology · 2024Review
- Healthcare-Seeking Delays in Acute Ischemic Stroke Patients: The Influence of Gender, Immigrant Status, and Educational Background.Risk management and healthcare policy · 2024Article
- GPR39 Knockout Worsens Microcirculatory Response to Experimental Stroke in a Sex-Dependent Manner.Translational stroke research · 2023Article
- Successful endovascular thrombectomy 8 days after onset of acute ischemic stroke: A case report.Heliyon · 2023Article
- Identification of infarct core and ischemic penumbra using computed tomography perfusion and deep learning.Journal of medical imaging (Bellingham, Wash.) · 2023Article
- Predictors and clinical outcomes of post-coronary artery bypass grafting cerebrovascular strokes.The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2022Article
- Endovascular recanalization of acute ischemic stroke patients exhibiting large vessel occlusion after pulmonary lobectomy: case series.BMC neurology · 2022Article
- Transient Middle Cerebral Artery Occlusion with an Intraluminal Suture Enables Reproducible Induction of Ischemic Stroke in Mice.Bio-protocol · 2022Article
- Multiphysics Modelling and Simulation of Thrombolysis via Activated Platelet-Targeted Nanomedicine.Pharmaceutical research · 2022Article
- Dysphagia assessment in ischemic stroke after mechanical thrombectomy: When and how?Frontiers in neurology · 2022Article
- Impact of time between thrombolysis and endovascular thrombectomy on outcomes in patients with acute ischaemic stroke.Frontiers in neurology · 2022Article
- A Patient With (Initially) Non-Persistent Vertigo - A Posterior Circulation Stroke Case.Cureus · 2022Article
- The Safety of Intra-arterial Tirofiban during Endovascular Therapy after Intravenous Thrombolysis.AJNR. American journal of neuroradiology · 2021Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rapid, safe and effective arterial recanalisation to restore blood flow and improve functional outcome remains the primary goal of hyperacute ischaemic stroke management. The benefit of intravenous thrombolysis with recombinant tissue-type plasminogen activator for patients with severe stroke due to large artery occlusion is limited; early recanalisation is generally less than 30% for carotid, proximal middle cerebral artery or basilar artery occlusion. Since November 2014, nine positive randomised controlled trials of mechanical thrombectomy for large vessel occlusion in the anterior circulation have led to a revolution in the care of patients with acute ischaemic stroke. Its efficacy is unmatched by any previous therapy in stroke medicine, with a number needed to treat of less than 3 for improved functional outcome. With effectiveness shown beyond any reasonable doubt, the key challenge now is how to implement accessible, safe and effective mechanical thrombectomy services. This review aims to provide neurologists and other stroke physicians with a summary of the evidence base, a discussion of practical aspects of delivering the treatment and future challenges. We aim to give guidance on some of the areas not clearly described in the clinical trials (based on evidence where available, but if not, on our own experience and practice) and highlight areas of uncertainty requiring further research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.