Evidence map›Paper›PMID 28647688›Full record

ArticleJournal of the American Heart Association2017

Antihypertensive Medication Adherence and Risk of Cardiovascular Disease Among Older Adults: A Population-Based Cohort Study.

Quanhe Yang, Anping Chang, Matthew D Ritchey, Fleetwood Loustalot

Abstract read
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Article in Journal of the American Heart Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

64 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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  17. Performance of Medication Tasks: Relationship Among Patient-Reported Outcomes, Performance-Based Assessments, and Objective Assessments.The American journal of occupational therapy : official publication of the American Occupational Therapy Association · 2024
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4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Quanhe YangDivision for Heart Disease and Stroke Prevention, Centers for Disease Control and Prevention, Atlanta, GA qay0@cdc.gov.
Anping ChangDivision for Heart Disease and Stroke Prevention, Centers for Disease Control and Prevention, Atlanta, GA.
Matthew D RitcheyDivision for Heart Disease and Stroke Prevention, Centers for Disease Control and Prevention, Atlanta, GA.
Fleetwood LoustalotDivision for Heart Disease and Stroke Prevention, Centers for Disease Control and Prevention, Atlanta, GA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAntihypertension medication (antihypertensive) adherence lowers risk of cardiovascular disease (CVD); few studies have examined this association among older adults. METHODS AND

resultsWe assessed this association among Medicare fee-for-service beneficiaries aged 66 to 79 years who were newly diagnosed with hypertension and initiated on antihypertensives in 2008-2009 (n=155 597). We calculated proportion of days covered (PDC) during follow-up, using proportional subdistribution hazard models, to examine association between antihypertensive adherence and a composite CVD outcomes, including first incident of fatal/nonfatal acute myocardial infarction, ischemic heart disease, stroke/transient ischemic attack, and heart failure. During follow-up (median 5.8 years and 798 621 person-years), we documented 47 198 CVD events. Among beneficiaries, 60.8%, 30.3%, and 8.9% had PDC ≥80%, 40% to 79%, and <40%. Crude incidence of CVD events were 40.1 (95% CI, 40.0-40.1), 93.9 (93.8-93.9), and 98.1 (98.1-98.2) per 1000 person-years for PDC ≥80%, 40% to 79%, and <40%, respectively. Adjusted hazard ratios for CVD events were 1.0 (<40% as reference), 1.0 (0.97-1.03) for 40% to 79%, and 0.44 (0.42-0.45) for ≥80% (

conclusionsAntihypertensive adherence was associated with a significantly lower risk of CVD events among older adults. There appeared to be a threshold effect in reducing CVD events at around PDC 80%, above which the risk for CVD reduced substantially.

Indexed as

Medication AdherenceAgedAntihypertensive AgentsChi-Square DistributionFemaleHeart FailureHumansHypertensionIschemic Attack, TransientMaleMedicareMultivariate AnalysisMyocardial InfarctionNonlinear DynamicsProportional Hazards ModelsProtective FactorsAntihypertensive Agentscardiovascular diseasehypertensionMedicaremedication adherenceprevention

Identifiers

PMID28647688
PMCPMC5669200

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.