Evidence map›Paper›PMID 28647669›Full record

ArticleJournal of affective disorders2017

"Engage" therapy: Prediction of change of late-life major depression.

George S Alexopoulos, Robert O'Neil, Samprit Banerjee, Patrick J Raue, Lindsay W Victoria, Jennifer N Bress, Cristina Pollari, Patricia A Arean

Abstract read
In one paragraph

Article in Journal of affective disorders, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 26 citations in OpenAlex.

  1. Resting State Functional Connectivity and Outcomes of Psychotherapies for Late-Life Depression.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2020
    Trial
  2. Engagement in Socially and Interpersonally Rewarding Activities as a Predictor of Outcome in "Engage" Behavioral Activation Therapy for Late-Life Depression.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2019
    Trial
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  10. Late Life Depression: The Essentials and the Essential Distinctions.Focus (American Psychiatric Publishing) · 2021
    Article
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  15. Empirically supported interventions in psychology: contributions of Research Domain Criteria.Psicologia, reflexao e critica : revista semestral do Departamento de Psicologia da UFRGS · 2019
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

George S AlexopoulosWeill-Cornell Institute of Geriatric Psychiatry, United States. Electronic address: gsalexop@med.cornell.edu.
Robert O'NeilWeill Cornell Medical College, Department of Healthcare Policy and Research, United States.
Samprit BanerjeeWeill-Cornell Institute of Geriatric Psychiatry, United States; Weill Cornell Medical College, Department of Healthcare Policy and Research, United States.
Patrick J RaueUniversity of Washington, Department of Psychiatry and Behavioral Sciences, United States.
Lindsay W VictoriaWeill-Cornell Institute of Geriatric Psychiatry, United States.
Jennifer N BressWeill-Cornell Institute of Geriatric Psychiatry, United States.
Cristina PollariWeill-Cornell Institute of Geriatric Psychiatry, United States.
Patricia A AreanUniversity of Washington, Department of Psychiatry and Behavioral Sciences, United States.
Cornell University · USUniversity of Washington · US

Funding

Research Methods CoreP30MH085943 · NIMH · WEILL MEDICAL COLL OF CORNELL UNIV · PI ALEXOPOULOS, GEORGE S · 2009 to 2013
$9.2M
RESEARCH TRAINING IN GERIATRIC MOOD DISORDERST32MH019132 · NIMH · WEILL MEDICAL COLL OF CORNELL UNIV · PI GUNNING, FAITH M · 1990 to 2025
$3.4M
Target engagement of a reward exposure therapy (Engage) for late life depressionR01MH102252 · NIMH · WEILL MEDICAL COLL OF CORNELL UNIV · PI ALEXOPOULOS, GEORGE S · 2014 to 2018
$2.0M
PST in Geriatric Depression with Executive DysfunctionR01MH064099 · NIMH · WEILL MEDICAL COLL OF CORNELL UNIV · PI SCHULBERG, HERBERT CHARLES · 2002 to 2006
$1.8M
Treating Depression in Low-Income Elderly with CIND/AMCIK24MH074717 · NIMH · UNIVERSITY OF WASHINGTON · PI AREAN, PATRICIA A. · 2005 to 2016
$1.7M
Case Management and PST for Depressed Homebound Low-Income EldersR01MH075900 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AREAN, PATRICIA A. · 2007 to 2011
$1.6M
NIMH NIH HHS K24 MH074717NIMH NIH HHS P30 MH085943NIMH NIH HHS R01 MH064099NIMH NIH HHS R01 MH075900NIMH NIH HHS R01 MH102252NIMH NIH HHS T32 MH019132
6 · The paper itself

Abstract

objectiveEngage grew out of the need for streamlined psychotherapies that can be accurately used by community therapists in late-life depression. Engage was based on the view that dysfunction of reward networks is the principal mechanism mediating depressive symptoms. Accordingly, Engage uses "reward exposure" (exposure to meaningful activities) and assumes that repeated activation of reward networks will normalize these systems. This study examined whether change in a behavioral activation scale, an index of reward system function, predicts change in depressive symptomatology.

methodsThe participants (N = 48) were older adults with major depression treated with 9 weekly sessions of Engage and assessed 27 weeks after treatment. Depression was assessed with the 24-item Hamilton Depression Rating Scale (HAM-D) and behavioral activation with the four subscales of Behavioral Activation for Depression Scale (activation, avoidance/rumination, work impairment, social impairment) at baseline, 6 weeks (mid-treatment), 9 weeks (end of treatment), and 36 weeks.

resultsChange only in the Activation subscale during successive periods of assessment predicted depression severity (HAM-D) at the end of each period (F LIMITATIONS: No comparison group. Partial overlap of Activation Subscale with HAM-D, lack of detailed neurocognitive assessment and social support.

conclusionChange in behavioral activation predicts improvement of depressive symptoms and signs in depressed older adults treated with Engage.

Indexed as

AgedBehavior TherapyFemaleFollow-Up StudiesHumansMajor Depressive DisorderMaleMiddle AgedPsychiatric Status Rating ScalesRewardTreatment Outcome

Identifiers

PMID28647669
PMCPMC5564217
OpenAlexW2720071953

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.