Evidence map›Paper›PMID 28647649›Full record

ArticleArchives of oral biology2017

Recovery after PILP remineralization of dentin lesions created with two cariogenic acids.

K Saeki, Y-C Chien, G Nonomura, A F Chin, S Habelitz, L B Gower, S J Marshall, G W Marshall

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Archives of oral biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Harnessing biomolecules for bioinspired dental biomaterials.Journal of materials chemistry. B · 2020
    Review
  11. Integrating the PILP-mineralization process into a restorative dental treatment.Dental materials : official publication of the Academy of Dental Materials · 2019
    Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

K SaekiDepartment of Preventive and Restorative Dental Sciences, University of California, San Francisco, 707 Parnassus Avenue, San Francisco, CA, 94143-0758, USA. Electronic address: kuniko.saeki@ucsf.edu.
Y-C ChienDepartment of Preventive and Restorative Dental Sciences, University of California, San Francisco, 707 Parnassus Avenue, San Francisco, CA, 94143-0758, USA.
G NonomuraDepartment of Preventive and Restorative Dental Sciences, University of California, San Francisco, 707 Parnassus Avenue, San Francisco, CA, 94143-0758, USA.
A F ChinDepartment of Preventive and Restorative Dental Sciences, University of California, San Francisco, 707 Parnassus Avenue, San Francisco, CA, 94143-0758, USA.
S HabelitzDepartment of Preventive and Restorative Dental Sciences, University of California, San Francisco, 707 Parnassus Avenue, San Francisco, CA, 94143-0758, USA.
L B GowerDepartment of Materials Science and Engineering, University of Florida, Gainesville, FL 32611-6400, USA.
S J MarshallDepartment of Preventive and Restorative Dental Sciences, University of California, San Francisco, 707 Parnassus Avenue, San Francisco, CA, 94143-0758, USA.
G W MarshallDepartment of Preventive and Restorative Dental Sciences, University of California, San Francisco, 707 Parnassus Avenue, San Francisco, CA, 94143-0758, USA.

Funding

DENTIN STRUCTURE, DEMINERALIZATION AND REMINERALIZATIONR01DE016849 · NIDCR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GOWER, LAURIE B, HABELITZ, STEFAN FRIEDRICH · 2006 to 2016
$5.1M
NIDCR NIH HHS R01 DE016849
6 · The paper itself

Abstract

objectivesAcetate and lactate are important cariogenic acids produced by oral bacteria. They produced different residual dentin structures in artificial lesions of similar depth. We evaluated if such lesions responded in the same way to a polymer-induced-liquid-precursor (PILP) remineralization.

designDentin blocks obtained from human third molars, divided into 6 groups (n=3). Blocks were demineralized with acetate (66h) or lactate (168h) buffer at pH 5.0 to create 140μm target lesion depths. A-DEM and L-DEM groups received no remineralization. Other groups were remineralized for 14days. 100μg/mL polyaspartate was added into the remineralizing buffer for A-PIL and L-PIL, whereas A-CAP and L-CAP were treated with the same solution but without polyaspartate. Cross-sectioned blocks were examined for shrinkage and AFM-topography. Line profiles of reduced elastic modulus (E

resultsA-PIL and L-PIL recovered in shrinkage to the original height of the dentin and it appeared normal with tubules, with increases in E

conclusionsThe PILP process provided significant recovery of both structure and mechanical properties for artificial lesions produced with acetate or lactate.

Indexed as

AcetatesDentinElastic ModulusHumansIn Vitro TechniquesLactic AcidMicroscopy, Atomic ForceMicroscopy, Electron, TransmissionMolar, ThirdPeptidesPolymersSurface PropertiesTooth DemineralizationTooth RemineralizationAcetatesLactic AcidPeptidespolyaspartatePolymersAtomic force microscopyDemineralizationDentin caries modelsNanomechanical propertyPILP mineralizationRemineralization

Identifiers

PMID28647649
PMCPMC5600685

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.