ArticleJournal of neuroscience methods2017
Age-related changes in structural connectivity are improved using subject-specific thresholding.
Article in Journal of neuroscience methods, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Alterations of white matter connectivity in alopecia areata patients.Brain imaging and behavior · 2026Article
- Aberrant White Matter Development in Cerebral Visual Impairment: A Proposed Mechanism for Visual Dysfunction Following Early Brain Injury.Journal of integrative neuroscience · 2024Article
- Comparison of local activation, functional connectivity, and structural connectivity in the N-back task.Frontiers in neuroscience · 2024Article
- Alterations in the Structural and Functional Connectivity of the Visuomotor Network of Children With Periventricular Leukomalacia.Seminars in pediatric neurology · 2019Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundDeterministic diffusion tractography obtained from high angular resolution diffusion imaging (HARDI) requires user-defined quantitative anisotropy (QA) thresholds. Most studies employ a common threshold across all subjects even though there is a strong degree of individual variation within groups. We sought to explore whether it would be beneficial to use individual thresholds in order to accommodate individual variance. To do this, we conducted two independent experiments.
methodFirst, tractography of the arcuate fasciculus and network connectivity measures were examined in a sample of 14 healthy participants. Second, we assessed the effects of QA threshold on group differences in network connectivity measures between healthy young (n=19) and old (n=14) individuals.
resultsThe results of both experiments were significantly influenced by QA threshold. Common thresholds set too high failed to produce sufficient reconstructions in most subjects, thus decreasing the likelihood of detecting meaningful group differences. On the other hand, common thresholds set too low resulted in spurious reconstructions, providing deleterious results. COMPARISON WITH EXISTING
methodsSubject specific thresholds acquired using our QA threshold selection method (QATS) appeared to provide the most meaningful networks while ensuring that data from all subjects contributed to the analyses.
conclusionsTogether, these results support the use of a subject-specific threshold to ensure that data from all subjects are included in the analyses being conducted.
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