Evidence map›Paper›PMID 28647284›Full record

Trial reportJournal of science and medicine in sport2018

The effects of high intensity interval training on muscle size and quality in overweight and obese adults.

Malia N M Blue, Abbie E Smith-Ryan, Eric T Trexler, Katie R Hirsch

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Journal of science and medicine in sport, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
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  8. Beyond weight loss: the value of physical activity and exercise for improving cardiometabolic risk factors in individuals with overweight and obesity.Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation · 2026
    Review
  9. Review
  10. Article
  11. Article
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  15. Strategies for Improving Firefighter Health On-Shift: A Review.Journal of functional morphology and kinesiology · 2024
    Review
  16. Article
  17. Muscle Ultrasound Echo Intensity and Fiber Type Composition in Young Females.Journal of functional morphology and kinesiology · 2024
    Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Malia N M BlueApplied Physiology Laboratory, Department of Exercise and Sport Science, University of North Carolina, USA; Human Movement Science Curriculum, Department of Allied Health Science, University of North Carolina, USA.
Abbie E Smith-RyanApplied Physiology Laboratory, Department of Exercise and Sport Science, University of North Carolina, USA; Human Movement Science Curriculum, Department of Allied Health Science, University of North Carolina, USA. Electronic address: abbsmith@email.unc.edu.
Eric T TrexlerApplied Physiology Laboratory, Department of Exercise and Sport Science, University of North Carolina, USA; Human Movement Science Curriculum, Department of Allied Health Science, University of North Carolina, USA.
Katie R HirschApplied Physiology Laboratory, Department of Exercise and Sport Science, University of North Carolina, USA; Human Movement Science Curriculum, Department of Allied Health Science, University of North Carolina, USA.

Funding

UNIV OF NORTH CAROLINA CLINICAL NUTRITION RESEARCH UNITP30DK056350 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Venkata Saroja Voruganti · 1999 to 2026
$31.6M
North Carolina Translational & Clinical Sciences Institute (NC TraCS)KL2TR001109 · NCATS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BUSE, JOHN BERNARD, CAREY, TIMOTHY S · 2013 to 2017
$5.7M
NCATS NIH HHS KL2 TR001109NIDDK NIH HHS P30 DK056350
6 · The paper itself

Abstract

objectivesDespite growing popularity of high intensity interval training (HIIT) for improving health and fitness, limited data exist identifying the effects of HIIT on muscle characteristics. The purpose of the current study was to investigate the effects of a 3-week HIIT intervention on muscle size and quality in overweight and obese men and women.

designRandomized controlled trial.

methodsForty-four overweight and obese men and women (mean±SD; age: 35.4±12.3years; height: 174.9±9.7cm; weight: 94.6±17.0kg; %fat: 32.7±6.5%) completed the current study. During baseline and post testing, muscle cross sectional area (mCSA) and echo intensity (EI) were determined from a panoramic scan of the vastus lateralis obtained by B-mode ultrasonography. Body composition variables were measured using dual energy X-ray absorptiometry. Participants were randomized into either a 1:1 work-to-rest ratio HIIT group (SIT; n=16), a 2:1 work-to-rest ratio HIIT group (LIT; n=19), or control (CON; n=9). HIIT participants performed five, 2-min bouts (LIT) or 10, 1-min bouts (SIT) at 85-100% VO

resultsAnalysis of covariance demonstrated a significant increase in mCSA for SIT (p=0.038; change (Δ)=3.17±3.36cm

conclusionsHIIT may be an effective exercise modality to influence muscle size in overweight and obese individuals. Future studies should investigate muscle characteristics and remodeling in an overweight population following interventions of longer duration and varying work-to-rest protocols.

Indexed as

High-Intensity Interval TrainingAdultAnalysis of VarianceBicyclingBody CompositionFemaleHumansMaleMiddle AgedMuscle, SkeletalObesityUltrasonographyYoung AdultIntermittent exerciseIntramuscular fatMuscle tissue

Identifiers

PMID28647284
PMCPMC7104622

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.