ArticleJournal of the American Academy of Child and Adolescent Psychiatry2017
Autism Spectrum Symptoms in a Tourette's Disorder Sample.
Article in Journal of the American Academy of Child and Adolescent Psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it, 75 citations in OpenAlex.
- Tourette syndrome research highlights from 2017.F1000Research · 2018Pooled it
- Understanding the Influence of Social and Motor Context on the Co-occurring Frequency of Restricted and Repetitive Behaviors in Autism.Journal of autism and developmental disorders · 2020Trial
- Autism and attention-deficit/hyperactivity disorder traits as predictors of tic phenomenology in children and adolescents.European child & adolescent psychiatry · 2026Article
- From cradle to Tic: early developmental profiles of tourette syndrome and its comorbidities in the MoBa cohort.European child & adolescent psychiatry · 2026Article
- The spectrum of neurodevelopmental disorders: comorbidities as clues to pathogenesis.Current opinion in psychiatry · 2026Review
- Computational Identification of Blood-Brain Barrier-Permeant Microbiome Metabolites with Binding Affinity to Neurotransmitter Receptors in Neurodevelopmental Disorders.Molecules (Basel, Switzerland) · 2026Article
- Health Care Encounters and Expenditures Among Children With Diagnosed Tic Disorders and Co-Occurring Disorders, 2022.Psychiatric services (Washington, D.C.) · 2025Article
- Neuropsychiatric symptoms in siblings of children with Tourette syndrome in the EMTICS study.JCPP advances · 2025Article
- The role of DPP6 dysregulation in neuropathology: from synaptic regulation to disease mechanisms.Frontiers in cellular neuroscience · 2025Review
- Neurodevelopmental Disorders and Connective Tissue-Related Symptoms: An Exploratory Case-Control Study in Children.Children (Basel, Switzerland) · 2024Article
- Chronic Tic Disorders in Youth: Clinical Phenotypes and Response to Pharmacological Treatment with Aripiprazole.Children (Basel, Switzerland) · 2024Article
- Developing a phenotype risk score for tic disorders in a large, clinical biobank.Translational psychiatry · 2024Article
- Sensory phenomena in children with Tourette syndrome or autism spectrum disorder.Frontiers in psychiatry · 2024Article
- Clinical characteristics of comorbid tic disorders in autism spectrum disorder: exploratory analysis.Child and adolescent psychiatry and mental health · 2023Article
- The hidden link between circadian entropy and mental health disorders.Translational psychiatry · 2022Review
- European clinical guidelines for Tourette syndrome and other tic disorders-version 2.0. Part I: assessment.European child & adolescent psychiatry · 2022Review
- Dopamine-2 receptor antibody encephalitis presenting as pure tongue-biting in a tourette syndrome patient: a case report.BMC psychiatry · 2022Article
- Mothers' accounts of mealtime and feeding challenges for children with Tourette syndrome or persistent tic disorders.Frontiers in psychiatry · 2022Article
- Common targetable inflammatory pathways in brain transcriptome of autism spectrum disorders and Tourette syndrome.Frontiers in neuroscience · 2022Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors at 12 institutions in 3 countries.
Funding
Abstract
objectiveTourette's disorder (TD) and autism spectrum disorder (ASD) share clinical features and possibly an overlapping etiology. The aims of this study were to examine ASD symptom rates in participants with TD, and to characterize the relationships between ASD symptom patterns and TD, obsessive-compulsive disorder (OCD), and attention-deficit/hyperactivity disorder (ADHD).
methodParticipants with TD (n = 535) and their family members (n =234) recruited for genetic studies reported TD, OCD, and ADHD symptoms and completed the Social Responsiveness Scale Second Edition (SRS), which was used to characterize ASD symptoms.
resultsSRS scores in participants with TD were similar to those observed in other clinical samples but lower than in ASD samples (mean SRS total raw score = 51; SD = 32.4). More children with TD met cut-off criteria for ASD (22.8%) than adults with TD (8.7%). The elevated rate in children was primarily due to high scores on the SRS Repetitive and Restricted Behaviors (RRB) subscale. Total SRS scores were correlated with TD (r = 0.27), OCD (r = 0.37), and ADHD (r = 0.44) and were higher among individuals with OCD symptom-based phenotypes than for those with tics alone.
conclusionHigher observed rates of ASD among children affected by TD may in part be due to difficulty in discriminating complex tics and OCD symptoms from ASD symptoms. Careful examination of ASD-specific symptom patterns (social communication vs. repetitive behaviors) is essential. Independent of ASD, the SRS may be a useful tool for identifying patients with TD with impairments in social communication that potentially place them at risk for bullying and other negative sequelae.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.