Trial reportJournal of the American Academy of Child and Adolescent Psychiatry2017
Striatal Activation Predicts Differential Therapeutic Responses to Methylphenidate and Atomoxetine.
Trial report in Journal of the American Academy of Child and Adolescent Psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00183391 (Measuring and Predicting Response to Atomoxetine and Methylphenidate), which is not on this map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Measuring and Predicting Response to Atomoxetine and Methylphenidate
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Tourette syndrome research highlights from 2017.F1000Research · 2018Pooled it
- Catecholaminergic Modulation of Large-Scale Network Dynamics Is Tied to the Reconfiguration of Corticostriatal Connectivity.Human brain mapping · 2024Trial
- Neuroimaging as a Tool for Advancing Pediatric Psychopharmacology.Paediatric drugs · 2025Review
- Neural basis for individual differences in the attention-enhancing effects of methylphenidate.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Neural and Cognitive Predictors of Stimulant Treatment Efficacy in Medication-Naïve ADHD Adults: A Pilot Diffusion Tensor Imaging Study.Journal of attention disorders · 2024Article
- Translating Decades of Neuroscience Research into Diagnostic and Treatment Biomarkers for ADHD.Advances in neurobiology · 2024Review
- Neuropsychological correlates of ADHD: indicators of different attentional profiles among youth with sluggish cognitive tempo.Frontiers in child and adolescent psychiatry · 2023Article
- Treatment biomarkers for ADHD: Taking stock and moving forward.Translational psychiatry · 2022Review
- Therapeutic Approaches for ADHD by Developmental Stage and Clinical Presentation.International journal of environmental research and public health · 2022Review
- Task-Based Functional Connectivity in Attention-Deficit/Hyperactivity Disorder: A Systematic Review.Biological psychiatry global open science · 2022Review
- Toward Precision Medicine in ADHD.Frontiers in behavioral neuroscience · 2022Review
- Responsivity of the Striatal Dopamine System to Methylphenidate-A Within-Subject I-123-β-CIT-SPECT Study in Male Children and Adolescents With Attention-Deficit/Hyperactivity Disorder.Frontiers in psychiatry · 2022Article
- When Helping Is Risky: The Behavioral and Neurobiological Trade-off of Social and Risk Preferences.Psychological science · 2021Article
- The norepinephrine transporter gene modulates intrinsic brain activity, visual memory, and visual attention in children with attention-deficit/hyperactivity disorder.Molecular psychiatry · 2021Article
- Structural brain network topology underpinning ADHD and response to methylphenidate treatment.Translational psychiatry · 2021Article
- Influence of Atomoxetine on Relationship Between ADHD Symptoms and Prefrontal Cortex Activity During Task Execution in Adult Patients.Frontiers in human neuroscience · 2021Article
- Localising movement disorders in childhood.The Lancet. Child & adolescent health · 2019Review
- Validating molecular target-enriched fMRI for disentangling drug effects on dopamine.Imaging neuroscience (Cambridge, Mass.)Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
objectiveMethylphenidate has prominent effects in the dopamine-rich striatum that are absent for the selective norepinephrine transporter inhibitor atomoxetine. This study tested whether baseline striatal activation would predict differential response to the two medications in youth with attention-deficit/hyperactivity disorder (ADHD).
methodA total of 36 youth with ADHD performed a Go/No-Go test during functional magnetic resonance imaging at baseline and were treated with methylphenidate and atomoxetine using a randomized cross-over design. Whole-brain task-related activation was regressed on clinical response.
resultsTask-related activation in right caudate nucleus was predicted by an interaction of clinical responses to methylphenidate and atomoxetine (F
conclusionEnhanced caudate activation for response inhibition may be a candidate biomarker of superior response to methylphenidate over atomoxetine in youth with ADHD, purportedly reflecting the dopaminergic effects of methylphenidate but not atomoxetine in the striatum, whereas motor cortex activation may predict response to atomoxetine. These data do not yet translate directly to the clinical setting, but the approach is potentially important for informing future research and illustrates that it may be possible to predict differential treatment response using a biomarker-driven approach. CLINICAL TRIAL REGISTRATION INFORMATION: Stimulant Versus Nonstimulant Medication for Attention Deficit Hyperactivity Disorder in Children; https://clinicaltrials.gov/; NCT00183391.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.