ArticleMicrobiome2017
How holobionts get sick-toward a unifying scheme of disease.
Article in Microbiome, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed.
- Multi-omics analysis reveals the pathobiome-host interactions in the bleaching disease of the seaweed Saccharina japonica.Microbiome · 2025Article
- Microbiome-based prediction of allogeneic hematopoietic stem cell transplantation outcome.Genome medicine · 2025Article
- Microbes Saving Lives and Reducing Suffering.Microbial biotechnology · 2025Article
- Microbiome shifts duringPeerJ · 2025Article
- Unpacking the sepsis controversy.Trauma surgery & acute care open · 2025Review
- Article
- Exploring the potential effects of forest urbanization on the interplay between small mammal communities and their gut microbiota.Animal microbiome · 2024Article
- Core hyphosphere microbiota of Fusarium oxysporum f. sp. niveum.Environmental microbiome · 2024Article
- The importance of the intestinal microbiota in humans and dogs in the neonatal period.Animal reproduction · 2023Review
- Infection by a eukaryotic gut parasite in wild Daphnia sp. associates with a distinct bacterial community.FEMS microbiology ecology · 2022Article
- A framework for testing the impact of co-infections on host gut microbiomes.Animal microbiome · 2022Review
- The Core Human Microbiome: Does It Exist and How Can We Find It? A Critical Review of the Concept.Nutrients · 2022Review
- The intestine and the microbiota in maternal glucose homeostasis during pregnancy.The Journal of endocrinology · 2022Review
- Concerted impacts of antiherbivore defenses and opportunistic Serratia pathogens on the fall armyworm (Spodoptera frugiperda).Oecologia · 2022Article
- The Interaction Between Viruses and Intestinal Microbiota: A Review.Current microbiology · 2021Review
- Projection of Gut Microbiome Pre- and Post-Bariatric Surgery To Predict Surgery Outcome.mSystems · 2021Article
- Developmental intestinal microbiome alterations in canine fading puppy syndrome: a prospective observational study.NPJ biofilms and microbiomes · 2021Article
- Relationship between gut microbiota and host-metabolism: Emphasis on hormones related to reproductive function.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2021Review
- Plants under the Attack of Allies: Moving towards the Plant Pathobiome Paradigm.Plants (Basel, Switzerland) · 2021Review
- Enteromorpha prolifera Diet Drives Intestinal Microbiome Composition in Siganus oramin.Current microbiology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
All humans, animals, and plants are holobionts. Holobionts comprise the host and a myriad of interacting microorganisms-the microbiota. The hologenome encompasses the genome of the host plus the composite of all microbial genomes (the microbiome). In health, there is a fine-tuned and resilient equilibrium within the members of the microbiota and between them and the host. This relative stability is maintained by a high level of microbial diversity, a delicate bio-geographic distribution of microorganisms, and a sophisticated and intricate molecular crosstalk among the multiple components of the holobiont. Pathobionts are temporarily benign microbes with the potential, under modified ecosystem conditions, to become key players in disease. Pathobionts may be endogenous, living for prolonged periods of time inside or on the host, or exogenous, invading the host during opportunistic situations. In both cases, the end result is the transformation of the beneficial microbiome into a health-perturbing pathobiome. We hypothesize that probably all diseases of holobionts, acute or chronic, infectious or non-infectious, and regional or systemic, are characterized by a perturbation of the healthy microbiome into a diseased pathobiome.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.