ArticleAnnals of clinical microbiology and antimicrobials2017
Prevalence of Chlamydia trachomatis, Neisseria gonorrhoeae, Mycoplasma genitalium and Ureaplasma urealyticum infections using a novel isothermal simultaneous RNA amplification testing method in infertile males.
Article in Annals of clinical microbiology and antimicrobials, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 42 citations in OpenAlex.
- Changing epidemiology of reproductive tract infections in Western China: a three-phase retrospective study during the COVID-19 pandemic.BMC infectious diseases · 2026Article
- Real-time polymerase chain reaction results of urogenital system samples and their relationship with other sexually transmitted diseases.Pakistan journal of medical sciences · 2026Article
- Infections of chlamydia trachomatis, mycoplasma genitalium and neisseria gonorrhoeae among the outpatients of reproductive medicine center in Chongqing, China: a retrospective study.BMC infectious diseases · 2025Article
- Ureaplasma urealyticum upregulates seminal fluid leukocytes and lowers human semen quality: a systematic review and meta-analysis.Basic and clinical andrology · 2025Review
- The possible pathogenic mechanisms of microorganisms in infertility: a narrative review.Archives of microbiology · 2025Review
- Article
- Prevalence of Site-SpecificInfection and drug resistance · 2025Article
- Prevalence of Ureaplasma species among patients at a tertiary hospital in China: a 10-year retrospective study from 2013 to 2022.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2023Article
- Comparison of analytical sensitivity of DNA-based and RNA-based nucleic acid amplification tests for reproductive tract infection pathogens: implications for clinical applications.Microbiology spectrum · 2023Article
- Are sexually transmitted infections associated with male infertility? A systematic review and in-depth evaluation of the evidence and mechanisms of action of 11 pathogens.Arab journal of urology · 2023Review
- Characteristics of common pathogens of urogenital tract among outpatients in Shanghai, China from 2016 to 2021.Frontiers in public health · 2023Article
- Analysis of Ureaplasma urealyticum, Chlamydia trachomatis, Mycoplasma genitalium and Neisseria gonorrhoeae infections among obstetrics and gynecological outpatients in southwest China: a retrospective study.BMC infectious diseases · 2022Article
- Bacteriospermia - A formidable player in male subfertility.Open life sciences · 2022Review
- Effect of bacterial infection on sperm quality and DNA fragmentation in subfertile men with Leukocytospermia.BMC molecular and cell biology · 2021Article
- Antimicrobial resistance, genetic characterization, and molecular epidemiology of Ureaplasma species in males with infertility.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2020Article
- What human sperm RNA-Seq tells us about the microbiome.Journal of assisted reproduction and genetics · 2020Article
- Examination of Ureaplasma urealyticum and Mycoplasma hominis in 4082 Chinese patients.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2020Article
- Microbial contamination in assisted reproductive technology: source, prevalence, and cost.Journal of assisted reproduction and genetics · 2020Review
- Comparison of rRNA-based and DNA-based nucleic acid amplifications for detection of Chlamydia trachomatis, Neisseria gonorrhoeae, and Ureaplasma urealyticum in urogenital swabs.BMC infectious diseases · 2018Article
- [Sexually transmitted infections and male fertility].Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete · 2018Review
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe purpose of this study was to evaluate the prevalence of Chlamydia trachomatis, Neisseria gonorrhoeae, Mycoplasma genitalium and Ureaplasma urealyticum infections in infertile men that consulted our outpatient departments using a novel simultaneous amplification testing (SAT) that is RNA-detection based. The possible impact of C. trachomatis, N. gonorrhoeae, M. genitalium and U. urealyticum infections on semen parameters was also noted in the present study.
methodsA total of 2607 males that were diagnosed with infertility were included in this study. C. trachomatis, N. gonorrhoeae, M. genitalium and U. urealyticum infections were detected in the urine samples using SAT method. Related data, including semen parameters and age as well as C. trachomatis, N. gonorrhoeae, M. genitalium and U. urealyticum infections were collected and analyzed.
resultsA total of 51 and 1418 urine samples were found positive for M. genitalium RNA and U. urealyticum RNA, respectively, while the prevalence of C. trachomatis and N. gonorrhoeae was relatively lower. Men with positive M. genitalium RNA and U. urealyticum RNA had higher sperm DNA fragmentation index (DFI) while the comparisons of other semen parameters yielded nonsignificant results between the RNA positive and negative group. A multivariate linear regression analysis revealed that U. urealyticum and M. genitalium infections posed significant factors of DFI (adjusted R
conclusionsOur study suggested a relative high prevalence of U. urealyticum and M. genitalium infection based on this novel SAT detection method. U. urealyticum and M. genitalium infection could possibly impair male fertility potential through promoting sperm DNA damage.
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