Evidence map›Paper›PMID 28646861›Full record

Observational studyBMC nephrology2017

C-terminal fragment of agrin (CAF) levels predict acute kidney injury after acute myocardial infarction.

Spyridon Arampatzis, Georgios Chalikias, Vasilios Devetzis, Stavros Konstantinides, Uyen Huynh-Do, Dimitrios Tziakas

Open access · goldAbstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in BMC nephrology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Spyridon ArampatzisDepartment of Nephrology, Hypertension and Clinical Pharmacology, Inselspital, University Hospital Bern, 3010, Bern, Switzerland. spyridon.arampatzis@insel.ch.
Georgios ChalikiasCardiology Department, Medical School, Democritus University of Thrace, Alexandroupolis, Greece.
Vasilios DevetzisDepartment of Nephrology, Hypertension and Clinical Pharmacology, Inselspital, University Hospital Bern, 3010, Bern, Switzerland.
Stavros KonstantinidesCardiology Department, Medical School, Democritus University of Thrace, Alexandroupolis, Greece.
Uyen Huynh-DoDepartment of Nephrology, Hypertension and Clinical Pharmacology, Inselspital, University Hospital Bern, 3010, Bern, Switzerland.
Dimitrios TziakasCardiology Department, Medical School, Democritus University of Thrace, Alexandroupolis, Greece.
Democritus University of Thrace · GRUniversity Hospital of Bern · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPatients with acute myocardial infarction are at high risk for acute kidney injury. Novel biomarkers that can predict acute kidney injury in AMI may allow timely interventions. C-terminal fragment of agrin (CAF), a proteoglycan of the glomerular and tubular basement membrane, have been recently associated with rapid renal function deterioration and proximal tubular dysfunction. It is unknown whether elevated CAF levels may serve as a novel AKI biomarker in patients presenting with AMI.

methodsIn 436 persons enrolled in a multicenter prospective observational cohort study of patients with acute myocardial infarction, we measured plasma and urine levels of several kidney injury biomarkers including CAF, neutrophil gelatinase-associated lipocalin (NGAL), interleukin-18 (IL-18) and cystatin-C.The relationship between biomarker levels at baseline and the development of AKI and long-term mortality were analyzed after adjustment for demographic and clinical variables.

resultsAKI incidence was up to 15% during hospitalization. The predictive accuracy for AKI of urinary CAF was similar to NGAL and superior to other tested kidney injury biomarkers. In a multivariate model that included all possible confounding variables only urinary CAF continued to be an independent marker for AKI (OR 1.35 95%CI 1.05 -1.74). During the 2 years follow-up, only plasma CAF levels remained a significant independent predictor of mortality (OR 2.5 95%CI 1.02-6.2; P = 0.04).

conclusionsElevated CAF levels are associated with AKI in patients with acute myocardial infarction. Our study provides preliminary evidence that CAF levels may predict AKI and mortality after AMI in low risk patients with relative preserved kidney function at baseline.

Indexed as

Acute Kidney InjuryAgedAgrinBiomarkersCohort StudiesFemaleHumansMaleMiddle AgedMyocardial InfarctionPeptide FragmentsPredictive Value of TestsProspective StudiesAgrinBiomarkersC-terminal agrin fragmentPeptide FragmentsAcute kidney injuryAcute myocardial infarctionBiomarkersC-terminal agrin fragment

Identifiers

PMID28646861
PMCPMC5483277
OpenAlexW2636938880

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.