ArticleBMC infectious diseases2017
Treatment delay and fatal outcomes of pulmonary tuberculosis in advanced age: a retrospective nationwide cohort study.
Article in BMC infectious diseases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 47 citations in OpenAlex.
- Trial
- Association between laboratory-based frailty index and unfavorable treatment outcomes in older adults with drug-susceptible pulmonary tuberculosis in the Republic of Korea: a retrospective cohort study.Frontiers in public health · 2026Article
- Tuberculosis patients' delay in healthcare access and its associated factors in Shandong Province, China.BMC public health · 2025Article
- Epidemic trend and spatial-temporal analysis of pulmonary tuberculosis in Hotan prefecture, xinjiang, china, 2015-2021.Scientific reports · 2025Article
- Diagnostic Delay Among Pulmonary Tuberculosis Patients Before, During and After COVID-19 Pandemic in Yichang City, China: A Longitudinal Study Based on Tuberculosis Surveillance Data.Journal of epidemiology and global health · 2025Article
- Trends and delays in pulmonary tuberculosis diagnosis among elderly patients (≥ 60 Years) in Southern China: a 13-year surveillance data analysis (2010-2022).BMC public health · 2025Article
- Explore the Application Value of Metagenomic Next-Generation Sequencing of Bronchoalveolar Lavage Fluid in the Early Diagnosis of Pulmonary Tuberculosis.Infection and drug resistance · 2025Article
- Global, regional, and national age-specific progress towards the 2020 milestones of the WHO End TB Strategy: a systematic analysis for the Global Burden of Disease Study 2021.The Lancet. Infectious diseases · 2024Article
- Changes in tuberculosis burden and its associated risk factors in Guizhou Province of China during 2006-2020: an observational study.BMC public health · 2024Observational
- Prediction of tuberculosis-specific mortality for older adult patients with pulmonary tuberculosis.Frontiers in public health · 2024Article
- Incidence of and Risk Factors for Acute Kidney Injury During Antituberculosis Treatment: A Prospective Cohort Study and Literature Review.Infectious diseases and therapy · 2023Article
- Clinic presentation delay and tuberculosis treatment outcomes in the Lake Victoria region of East Africa: A multi-site prospective cohort study.PLOS global public health · 2023Article
- Total delay and associated factors among tuberculosis patients in Jimma Zone, Southwest Ethiopia.PloS one · 2023Article
- Factors Associated with Medication Adherence in Elderly Individuals with Tuberculosis: A Qualitative Study.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2023Article
- Causes of pre-treatment loss to follow-up in patients with TB.Public health action · 2022Article
- Perceptions, Attitudes, Experiences and Opinions of Tuberculosis Associated Stigma: A Qualitative Study of the Perspectives among the Bolgatanga Municipality People of Ghana.International journal of environmental research and public health · 2022Article
- Nucleic acid amplification tests reduce delayed diagnosis and misdiagnosis of pulmonary tuberculosis.Scientific reports · 2022Article
- Delays in Diagnosis and Treatment in Patients Underwent Endobronchial Ultrasound-Transbronchial Needle Aspiration (EBUS-TBNA).International journal of clinical practice · 2022Article
- The probability of diagnostic delays for tuberculosis and its associated risk factors in northwest Iran from 2005 to 2016: a survival analysis using tuberculosis surveillance data.Epidemiology and health · 2022Article
- Healthcare-seeking delay during COVID-19 pandemic among tuberculosis patients in Ilubabor zone health facilities, south-west Ethiopia.SAGE open medicine · 2022Article
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectiveStudies focusing on pulmonary tuberculosis in advanced age (≥80 years) are lacking. This study aimed to explore treatment delay, outcomes and their predictors in this group.
methodsAdult (≥20 years) patients with pulmonary tuberculosis were identified from the National Health Insurance Research Database of Taiwan from 2004 to 2009. Treatment completion and mortality rates were noted at one year after treatment.
resultsAmong the 81,081 patients with pulmonary tuberculosis identified, 13,923 (17.2%) were aged ≥80 years, and 26,897 (33.2%) were aged 65-79 years. The treatment completion, mortality rates and treatment delay were 54.8%, 34.7% and 61 (12-128) [median, (1st-3rd quartiles)] days in patients aged ≥80 years, 68.3%, 18.5% and 53 (8-122) days in patients aged 65-79 years, and 78.9%, 6.5% and 21 (1-84) days in patients aged <65 years, respectively. The elder patients were more likely to receive second-line anti-tuberculosis agents. The treatment completion rate decreased with older age, female sex, comorbidities, low income, requiring second-line anti-tuberculosis agents, severity of pulmonary tuberculosis and longer treatment delay. Older age, female sex, comorbidities, low income, and not undergoing rapid molecular diagnostic tests were independently associated with longer treatment delays.
conclusionsPulmonary tuberculosis in advanced age has a longer treatment delay and a higher mortality rate. Applying rapid molecular diagnostic tools may reduce treatment delay and should be integrated into the diagnostic algorithm for pulmonary tuberculosis, particularly in elderly patients.
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