Evidence map›Paper›PMID 28646853›Full record

ArticleBMC veterinary research2017

Immunogenicity and protective efficacy of a Salmonella Enteritidis sptP mutant as a live attenuated vaccine candidate.

Zhijie Lin, Peipei Tang, Yang Jiao, Xilong Kang, Qiuchun Li, Xiulong Xu, Jun Sun, Zhiming Pan, Xinan Jiao

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC veterinary research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 26 citations in OpenAlex.

  1. Deletion ofFrontiers in microbiology · 2026
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  5. TheFrontiers in microbiology · 2025
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  6. PipC affects the virulence ofFrontiers in microbiology · 2025
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  7. Article
  8. Article
  9. Review
  10. Article
  11. Pathogens (Basel, Switzerland) · 2022
    Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Zhijie LinJiangsu Key Laboratory of Zoonosis, Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonosis, MOA Key Laboratory of Prevention and Control of Biological Hazard Factors (Animal Origin) for Agrifood Safety and Quality, MOE Joint International Research Laboratory of Agriculture and Agri-product Safety, Yangzhou University, Yangzhou, 225001, China.
Peipei TangJiangsu Key Laboratory of Zoonosis, Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonosis, MOA Key Laboratory of Prevention and Control of Biological Hazard Factors (Animal Origin) for Agrifood Safety and Quality, MOE Joint International Research Laboratory of Agriculture and Agri-product Safety, Yangzhou University, Yangzhou, 225001, China.
Yang JiaoJiangsu Key Laboratory of Zoonosis, Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonosis, MOA Key Laboratory of Prevention and Control of Biological Hazard Factors (Animal Origin) for Agrifood Safety and Quality, MOE Joint International Research Laboratory of Agriculture and Agri-product Safety, Yangzhou University, Yangzhou, 225001, China.
Xilong KangJiangsu Key Laboratory of Zoonosis, Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonosis, MOA Key Laboratory of Prevention and Control of Biological Hazard Factors (Animal Origin) for Agrifood Safety and Quality, MOE Joint International Research Laboratory of Agriculture and Agri-product Safety, Yangzhou University, Yangzhou, 225001, China.
Qiuchun LiJiangsu Key Laboratory of Zoonosis, Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonosis, MOA Key Laboratory of Prevention and Control of Biological Hazard Factors (Animal Origin) for Agrifood Safety and Quality, MOE Joint International Research Laboratory of Agriculture and Agri-product Safety, Yangzhou University, Yangzhou, 225001, China.
Xiulong XuJiangsu Key Laboratory of Zoonosis, Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonosis, MOA Key Laboratory of Prevention and Control of Biological Hazard Factors (Animal Origin) for Agrifood Safety and Quality, MOE Joint International Research Laboratory of Agriculture and Agri-product Safety, Yangzhou University, Yangzhou, 225001, China.
Jun SunJiangsu Key Laboratory of Zoonosis, Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonosis, MOA Key Laboratory of Prevention and Control of Biological Hazard Factors (Animal Origin) for Agrifood Safety and Quality, MOE Joint International Research Laboratory of Agriculture and Agri-product Safety, Yangzhou University, Yangzhou, 225001, China.
Zhiming PanJiangsu Key Laboratory of Zoonosis, Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonosis, MOA Key Laboratory of Prevention and Control of Biological Hazard Factors (Animal Origin) for Agrifood Safety and Quality, MOE Joint International Research Laboratory of Agriculture and Agri-product Safety, Yangzhou University, Yangzhou, 225001, China. zmpan@yzu.edu.cn.ORCID http://orcid.org/0000-0002-2685-6240
Xinan JiaoJiangsu Key Laboratory of Zoonosis, Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonosis, MOA Key Laboratory of Prevention and Control of Biological Hazard Factors (Animal Origin) for Agrifood Safety and Quality, MOE Joint International Research Laboratory of Agriculture and Agri-product Safety, Yangzhou University, Yangzhou, 225001, China. jiao@yzu.edu.cn.
Yangzhou University · CNRush University Medical Center · USUniversity of Illinois Chicago · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSalmonella enterica serovar Enteritidis (S. Enteritidis) is a highly adaptive pathogen in both humans and animals. As a Salmonella Type III secretion system (T3SS) effector, Salmonella protein tyrosine phosphatase (SptP) is critical for virulence in this genus. To investigate the feasibility of using C50336ΔsptP as a live attenuated oral vaccine in mice, we generated the sptP gene deletion mutant C50336ΔsptP in S. Enteritidis strain C50336 by λ-Red mediated recombination and evaluated the protective ability of the S. Enteritidis sptP mutant strain C50336ΔsptP against mice salmonellosis.

resultsWe found that C50336ΔsptP was a highly immunogenic, effective, and safe vaccine in mice. Compared to wild-type C50336, C50336ΔsptP showed reduced virulence as confirmed by the 50% lethal dose (LD

conclusionsThese results demonstrate that C50336ΔsptP can be a live attenuated oral vaccine for salmonellosis.

Indexed as

Administration, OralAnimalsBacterial ProteinsFemaleGene DeletionImmunizationMice, Inbred BALB CProtein Tyrosine PhosphatasesSalmonella enteritidisSalmonella Infections, AnimalSalmonella VaccinesVaccines, AttenuatedVirulenceBacterial ProteinsProtein Tyrosine PhosphatasesSalmonella VaccinesVaccines, AttenuatedImmune protectionImmunogenicitySalmonella EnteritidisSptPVaccine

Identifiers

PMID28646853
PMCPMC5483252
OpenAlexW2652755280

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.