SynthesisHeart failure reviews2017
Effects of catheter-based renal denervation on heart failure with reduced ejection fraction: a systematic review and meta-analysis.
Synthesis in Heart failure reviews, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Systematic review of renal denervation for the management of cardiac arrhythmias.Clinical research in cardiology : official journal of the German Cardiac Society · 2022Pooled it
- Effects of catheter-based renal denervation on heart failure with reduced ejection fraction: a meta-analysis of randomized controlled trials.Heart failure reviews · 2022Pooled it
- Efficacy and safety of catheter-based renal denervation for heart failure with reduced ejection fraction: a systematic review and meta-analysis.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2020Pooled it
- The effect of multiple-inflation balloon aortic valvuloplasty.Heart and vessels · 2020Pooled it
- Multi-Organ Denervation: The Past, Present and Future.Journal of clinical medicine · 2025Review
- Evaluating Veterans' Preferences for Renal Denervation for Treatment of Difficult-to-Control Hypertension: A Single-Center Survey Study.Health science reports · 2025Article
- Article
- A Japan nationwide web-based survey of patient preference for renal denervation for hypertension treatment.Hypertension research : official journal of the Japanese Society of Hypertension · 2022Article
- Contemporary Strategies to Manage High Blood Pressure in Patients with Coexistent Resistant Hypertension and Heart Failure With Reduced Ejection Fraction.Cardiology and therapy · 2021Review
- Effects of sympathectomy on myocardium remodeling and function.Clinics (Sao Paulo, Brazil) · 2021Article
- Ablating the renal nerves to treat heart failure with reduced ejection fraction: another treatment option in a crowded space?Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2020Article
- Proceedings from the 3rd European Clinical Consensus Conference for clinical trials in device-based hypertension therapies.European heart journal · 2020Article
- Autonomic Control of the Heart and Its Clinical Impact. A Personal Perspective.Frontiers in physiology · 2020Article
- Sympathetic nervous system in age-related cardiovascular dysfunction: Pathophysiology and therapeutic perspective.The international journal of biochemistry & cell biology · 2019Review
- Devices and interventions for the prevention of adverse outcomes of tachycardia on heart failure.Heart failure reviews · 2018Review
- Renal denervation therapy beyond resistant hypertension.Journal of thoracic disease · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite the recent advances in the management of heart failure, the mortality of heart failure patients remains high. It is of urgent need to develop new therapy for heart failure. Heart failure is characterized by increased sympathetic activity, and chronic sympathetic activation is involved in the maintenance of the pathological state. Catheter-based renal denervation (RDN) has emerged as an invasive but safe approach that can reduce sympathetic activation. Studies have reported inconsistent results regarding the effect of RDN in heart failure patients due to limited power with small sample sizes. We aimed to conduct a meta-analysis of the effect of RDN on heart failure patients with reduced left ventricular (LV) ejection fraction (EF). An electronic search for studies examining the effect of RDN on LV function in heart failure patients with reduced EF was conducted. Two controlled (80 patients) and 2 uncontrolled studies (21 patients) were included in this meta-analysis. In the pooled analysis, 6 months after RDN, there was a greater increase in EF (weighted mean difference [95% CI] = 8.63 [6.02, 11.24] %) and a greater decrease in LV end-diastolic diameter (-0.58 [-0.83, -0.34] cm) in RDN group than in control group. No serious adverse events such as acute renal artery stenosis and dissection occurred. Our meta-analysis of feasibility studies suggests that RDN may improve LV function in heart failure patients with reduced EF, providing the rationale to conduct next phase trials to confirm the observed potential benefits of RDN.
Indexed as
Identifiers
28646466What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.