ArticlePsychopharmacology2017
Regulation of sustained attention, false alarm responding and implementation of conditional rules by prefrontal GABA
Article in Psychopharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 15 citations in OpenAlex.
- Stage-Dependent Effects of "Too Little and Too Much" Medial Prefrontal Activity on Reversal Learning in Rats: Functional Inhibition Impairs Early, Whereas Neural Disinhibition Impairs Late Reversals.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Control of sustained attention and impulsivity by GTranslational psychiatry · 2023Article
- GABAJournal, genetic engineering & biotechnology · 2021Review
- Exposure to a high dose of amoxicillin causes behavioral changes and oxidative stress in young zebrafish.Metabolic brain disease · 2020Article
- Impaired theta phase coupling underlies frontotemporal dysconnectivity in schizophrenia.Brain : a journal of neurology · 2020Article
- Dissociable roles for the ventral and dorsal medial prefrontal cortex in cue-guided risk/reward decision making.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Article
- Contribution of GABABehavioural brain research · 2020Article
- Differential Contributions of Nucleus Accumbens Subregions to Cue-Guided Risk/Reward Decision Making and Implementation of Conditional Rules.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Vortioxetine Differentially Modulates MK-801-Induced Changes in Visual Signal Detection Task Performance and Locomotor Activity.Frontiers in pharmacology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
rationaleBoth prefrontal cortex (PFC) GABA
objectivesWe examined PFC GABA
methodsMale rats were well-trained on the SAT that required identifying whether a brief visual stimulus (500-50 ms) was present/absent by pressing one of two levers. They then received intra-PFC infusions of the GABA
resultsBoth doses of bicuculline impaired vigilance, selectively increasing errors during nonsignal trials. Intra-PFC MK-801 induced subtle impairments at short signal durations. Systemic MK-801 impaired performance and increased response latencies. Visual and auditory conditional discrimination was impaired by 50 ng, but not 12.5 ng of bicuculline.
conclusionsThese findings highlight a key role for PFC GABA transmission in reducing sensitivity to distractors during attentional performance. Furthermore, they reveal that disruption of GABA signaling can interfere with the ability to implement conditional rules.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.