Evidence map›Paper›PMID 28646365›Full record

ArticleCancer causes & control : CCC2017

Post-diagnosis serum insulin-like growth factors in relation to dietary and lifestyle changes in the Prostate testing for cancer and Treatment (ProtecT) trial.

Vanessa Er, Kalina Biernacka, Andrew J Simpkin, Richard M Martin, Mona Jeffreys, Pauline Emmett, Rebecca Gilbert, Kerry N L Avery, Eleanor Walsh, Michael Davis and 5 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer causes & control : CCC, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 1 country.

Vanessa ErSchool of Social and Community Medicine, University of Bristol, Canynge Hall, 39,Whatley Road, Bristol, BS8 2PS, UK. Vanessa.Er@bristol.ac.uk.ORCID http://orcid.org/0000-0002-0649-1846
Kalina BiernackaNational Institute for Health Research (NIHR) Bristol Nutrition Biomedical Research Unit, Level 3, University Hospitals Bristol Education & Research Centre, Upper Maudlin Street, Bristol, BS2 8AE, UK.
Andrew J SimpkinSchool of Social and Community Medicine, University of Bristol, Canynge Hall, 39,Whatley Road, Bristol, BS8 2PS, UK.
Richard M MartinSchool of Social and Community Medicine, University of Bristol, Canynge Hall, 39,Whatley Road, Bristol, BS8 2PS, UK.
Mona JeffreysSchool of Social and Community Medicine, University of Bristol, Canynge Hall, 39,Whatley Road, Bristol, BS8 2PS, UK.
Pauline EmmettSchool of Social and Community Medicine, University of Bristol, Canynge Hall, 39,Whatley Road, Bristol, BS8 2PS, UK.
Rebecca GilbertSchool of Social and Community Medicine, University of Bristol, Canynge Hall, 39,Whatley Road, Bristol, BS8 2PS, UK.
Kerry N L AverySchool of Social and Community Medicine, University of Bristol, Canynge Hall, 39,Whatley Road, Bristol, BS8 2PS, UK.
Eleanor WalshSchool of Social and Community Medicine, University of Bristol, Canynge Hall, 39,Whatley Road, Bristol, BS8 2PS, UK.
Michael DavisSchool of Social and Community Medicine, University of Bristol, Canynge Hall, 39,Whatley Road, Bristol, BS8 2PS, UK.
Jenny L DonovanSchool of Social and Community Medicine, University of Bristol, Canynge Hall, 39,Whatley Road, Bristol, BS8 2PS, UK.
David E NealNuffield Department of Surgical Sciences, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DU, UK.
Freddie C HamdyNuffield Department of Surgical Sciences, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DU, UK.
Jeff M P HollyNational Institute for Health Research (NIHR) Bristol Nutrition Biomedical Research Unit, Level 3, University Hospitals Bristol Education & Research Centre, Upper Maudlin Street, Bristol, BS2 8AE, UK.
J Athene LaneSchool of Social and Community Medicine, University of Bristol, Canynge Hall, 39,Whatley Road, Bristol, BS8 2PS, UK.
University of Bristol · GBJohn Radcliffe Hospital · GBNational Institute for Health Research · GBSouthmead Hospital · GB

Funding

Cancer Research UK 15194Cancer Research UK 19169Cancer Research UK A19169
6 · The paper itself

Abstract

purposeThe insulin-like growth factor (IGF) system is modifiable by diet and lifestyle, and has been linked to prostate cancer development and progression.

methodsWe conducted a prospective cohort study of 621 men diagnosed with localized prostate cancer to investigate the associations of dietary and lifestyle changes with post-diagnosis circulating levels of IGF-I and IGFBP-3. We used analysis of covariance to estimate the associations, controlling for baseline IGF-I or IGFBP-3, respectively.

resultsMean IGF-I levels were 6.5% (95% CI -12.8, -0.3%, p = 0.04) lower in men who decreased their protein intake after diagnosis compared to men who did not change. Men who changed their fruit and vegetable intake had lower IGF-I levels compared to non-changers [Decreased intake: -10.1%, 95% CI -18.4, -1.8%, p = 0.02; Increased intake: -12.0%, 95% CI -18.4, -1.8%, p = 0.002]. IGFBP-3 was 14.6% (95% CI -24.5, -4.8%, p = 0.004) lower in men who achieved a healthy body mass index after diagnosis. Men who became inactive had 9.5% higher average IGF-I levels (95% CI 0.1, 18.9%, p = 0.05).

conclusionsDecreased protein intake and body mass index, and increased physical activity and fruit and vegetable intake, following a prostate cancer diagnosis were associated with reduced post-diagnosis serum IGF-I and IGFBP-3. Counterintuitively, reduced fruit and vegetable intake was also associated with reduced IGF-I, but with weak statistical support, possibly implicating chance. If confirmed in other studies, our findings may inform potential lifestyle interventions in prostate cancer. ProtecT was registered at International Standard Randomised Controlled Trial Registry, http://isrctn.org as ISRCTN20141297.

Indexed as

DietLife StyleAgedBody Mass IndexDietary ProteinsExerciseFeeding BehaviorFruitHumansInsulin-Like Growth Factor Binding Protein 3Insulin-Like Growth Factor IMaleMiddle AgedProspective StudiesProstatic NeoplasmsVegetablesDietary ProteinsIGFBP3 protein, humanInsulin-Like Growth Factor Binding Protein 3Insulin-Like Growth Factor IDietInsulin-like growth factorsLifestylePost-diagnosisProstatic neoplasms

Identifiers

PMID28646365
PMCPMC5501895
OpenAlexW2630448918

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.