ArticleNeuroscience bulletin2017
Abnormal Rich-Club Organization Associated with Compromised Cognitive Function in Patients with Schizophrenia and Their Unaffected Parents.
Article in Neuroscience bulletin, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 32 citations in OpenAlex.
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- Long-term risk of late-life depression in widowed elderly: a five-year follow-up study.BMC geriatrics · 2025Article
- Altered default-mode and frontal-parietal network pattern underlie adaptiveness of emotion regulation flexibility following task-switch training.Social cognitive and affective neuroscience · 2024Article
- Age Trajectories of the Structural Connectome in Child and Adolescent Offspring of Individuals With Bipolar Disorder or Schizophrenia.Biological psychiatry global open science · 2024Article
- Genetic architecture of the structural connectome.Nature communications · 2024Article
- Graph theoretical analysis and independent component analysis of diabetic optic neuropathy: A resting-state functional magnetic resonance imaging study.CNS neuroscience & therapeutics · 2024Article
- Brain tissue segmentation in neurosurgery: a systematic analysis for quantitative tractography approaches.Acta neurologica Belgica · 2024Review
- Quantitative mapping of the brain's structural connectivity using diffusion MRI tractography: A review.NeuroImage · 2022Review
- Integrative omics of schizophrenia: from genetic determinants to clinical classification and risk prediction.Molecular psychiatry · 2022Review
- Altered white matter structural networks in drug-naïve patients with obsessive-compulsive disorder.Brain imaging and behavior · 2021Article
- White matter microstructure and network-connectivity in emerging adults with subclinical psychotic experiences.Brain imaging and behavior · 2020Article
- Magnetic Resonance Imaging-Based Connectomics in First-Episode Schizophrenia: From Preclinical Study to Clinical Translation.Frontiers in psychiatry · 2020Article
- Rich-club in the brain's macrostructure: Insights from graph theoretical analysis.Computational and structural biotechnology journal · 2020Review
- Synaptic Plasticity Shapes Brain Connectivity: Implications for Network Topology.International journal of molecular sciences · 2019Review
- Age-Related Reduction in Cortical Thickness in First-Episode Treatment-Naïve Patients with Schizophrenia.Neuroscience bulletin · 2019Article
- Independent Component Analysis and Graph Theoretical Analysis in Patients with Narcolepsy.Neuroscience bulletin · 2019Article
- Microstructural white matter network-connectivity in individuals with psychotic disorder, unaffected siblings and controls.NeuroImage. Clinical · 2019Article
- Understanding the Emergence of Neuropsychiatric Disorders With Network Neuroscience.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2018Review
- Research Progress in Biological Studies of Schizophrenia in China in 2017.Shanghai archives of psychiatry · 2018Review
- ZNF804A Variation May Affect Hippocampal-Prefrontal Resting-State Functional Connectivity in Schizophrenic and Healthy Individuals.Neuroscience bulletin · 2018Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Schizophrenia is considered to be a disorder of brain connectivity, which might result from a disproportionally impaired rich-club organization. The rich-club is composed of highly interconnected hub regions that play crucial roles in integrating information between different brain regions. Few studies have yet investigated whether the structural rich-club organization is impaired in patients and their first-degree relatives. In this study, we established a weighted network model of white matter connections using diffusion tensor imaging of 19 patients and 39 unaffected parents, 22 young healthy controls for the patients, and 25 old healthy controls for the parents. Feeder edges between rich-club nodes and non-rich-club nodes were significantly decreased in both schizophrenic patients and their unaffected parents compared with controls. Furthermore, the feeder edges showed significant positive correlations with the scores in Category Fluency Test-animal naming in the unaffected parents. Specific feeder edges exhibited discriminative power with accuracy of 84.4% in distinguishing unaffected parents from old healthy controls. Our findings suggest that impaired rich-club organization, especially impaired feeder edges, may be related to familial vulnerability to schizophrenia, possibly reflecting a genetic predisposition for schizophrenia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.