ReviewNeuroscience bulletin2018
Modeling Pain Using fMRI: From Regions to Biomarkers.
Review in Neuroscience bulletin, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06603168 (Autonomic Recalibration Approach to Myofascial Pain Elimination), which is not on this map. Cited by 64 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Autonomic Recalibration Approach to Myofascial Pain Elimination
Who cites it
64 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Identifying robust neural signatures of acupuncture modulation in healthy brains: a multimodal meta-analysis mapping core network.Frontiers in human neuroscience · 2025Pooled it
- Mindfulness Meditation and Placebo Modulate Distinct Multivariate Neural Signatures to Reduce Pain.Biological psychiatry · 2025Trial
- Neural Signatures of Pain Modulation in Short-Term and Long-Term Mindfulness Training: A Randomized Active-Control Trial.The American journal of psychiatry · 2022Trial
- Evidence for decreased Neurologic Pain Signature activation following thoracic spinal manipulation in healthy volunteers and participants with neck pain.NeuroImage. Clinical · 2019Trial
- Association of sexual dysfunctions according to DSM-5 criteria with structural brain differences in women and men from the Hamburg City Health Study.Dialogues in clinical neuroscience · 2026Article
- Application of generative artificial intelligence (AI) to support pain neuroscience research in persons who are pregnant.Communications medicine · 2026Article
- Abnormal Regional Brain Functional Activity and Brain Network Connectivity in Primary Trigeminal Neuralgia Patients: An Activation Likelihood Estimation Meta-Analysis Based on Resting-State fMRI.Journal of pain research · 2026Review
- Down-regulation of gastrin-releasing peptide in medial orbitofrontal cortex to nucleus accumbens projections contributes to allodynia and negative affect.Science advances · 2025Article
- Recent Advances in Unraveling the Mechanisms of Pain and Itch: The Third Special Issue.Neuroscience bulletin · 2025Article
- A cross-sectional analysis of brain structure, pain behaviors, and mental health in persons with surgically confirmed endometriosis.Communications biology · 2025Article
- Neural variability reliably encodes interindividual differences in the perception of pain intensity.PLoS biology · 2025Article
- Mendelian Randomization Analysis Reveal the Role of Circulating Inflammatory Proteins in Mediating Functional Brain Networks and Peripheral Neuropathic Pain Effects.Brain and behavior · 2025Article
- Action-mode subnetworks for decision-making, action control, and feedback.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Nature exposure induces analgesic effects by acting on nociception-related neural processing.Nature communications · 2025Article
- Chronic pain: a modifiable target to reduce perioperative cardiovascular morbidity.British journal of anaesthesia · 2025Article
- Gender differences in brain activity underlying acupuncture sensations at LR3: a task-based fMRI study.Frontiers in human neuroscience · 2025Article
- The Effectiveness of Thermal Stimulation Plus Conventional Therapy for Functional Recovery After Stroke: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2024Review
- Review
- Bibliometric analysis of functional magnetic resonance imaging studies on chronic pain over the past 20 years.Acta neurochirurgica · 2024Review
- Placebo treatment affects brain systems related to affective and cognitive processes, but not nociceptive pain.Nature communications · 2024Article
4 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pain is a subjective and complex phenomenon. Its complexity is related to its heterogeneity: multiple component processes, including sensation, affect, and cognition, contribute to pain experience and reporting. These components are likely to be encoded in distributed brain networks that interact to create pain experience and pain-related decision-making. Therefore, to understand pain, we must identify these networks and build models of these interactions that yield testable predictions about pain-related outcomes. We have developed several such models or 'signatures' of pain, by (1) integrating activity across multiple systems, and (2) using pattern-recognition to identify processes related to pain experience. One model, the Neurologic Pain Signature, is sensitive and specific to pain in individuals, involves brain regions that receive nociceptive afferents, and shows little effect of expectation or self-regulation in tests to date. Another, the 'Stimulus Intensity-Independent Pain Signature', explains substantial additional variation in trial-to-trial pain reports. It involves many brain regions that do not show increased activity in proportion to noxious stimulus intensity, including medial and lateral prefrontal cortex, nucleus accumbens, and hippocampus. Responses in this system mediate expectancy and perceived control effects in several studies. Overall, this approach provides a pathway to understanding pain by identifying multiple systems that track different aspects of pain. Such componential models can be combined in unique ways on a subject-by-subject basis to explain an individual's pain experience.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.