Evidence map›Paper›PMID 28646277›Full record

ArticleMycopathologia2017

Standardization and Prevalence of the Booster Phenomenon: Evaluation Using a Two-Step Skin Test with 43 kDa Glycoprotein in Individuals from an Endemic Region of Paracoccidioidomycosis.

Ana Paula C Marques, Sandra Maria V L Oliveira, Grazielli R Rezende, Dayane A Melo, Sonia M Fernandes-Fitts, Elenir Rose J C Pontes, Maria da Glória Bonecini-Almeida, Zoilo P Camargo, Rinaldo P Mendes, Anamaria M M Paniago

Open access · greenAbstract read
PubMed Publisher
In one paragraph

Article in Mycopathologia, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Ana Paula C MarquesFaculty of Medicine, Federal University of Mato Grosso do Sul, Cidade Universitária s/n, Campo Grande, 79070-900, Brazil. apcmarques@hotmail.com.ORCID http://orcid.org/0000-0003-4012-0720
Sandra Maria V L OliveiraFaculty of Medicine, Federal University of Mato Grosso do Sul, Cidade Universitária s/n, Campo Grande, 79070-900, Brazil.
Grazielli R RezendeFaculty of Medicine, Federal University of Mato Grosso do Sul, Cidade Universitária s/n, Campo Grande, 79070-900, Brazil.
Dayane A MeloFaculty of Medicine, Federal University of Mato Grosso do Sul, Cidade Universitária s/n, Campo Grande, 79070-900, Brazil.
Sonia M Fernandes-FittsFaculty of Medicine, Federal University of Mato Grosso do Sul, Cidade Universitária s/n, Campo Grande, 79070-900, Brazil.
Elenir Rose J C PontesFaculty of Medicine, Federal University of Mato Grosso do Sul, Cidade Universitária s/n, Campo Grande, 79070-900, Brazil.
Maria da Glória Bonecini-AlmeidaLaboratory of Immunology and Immunogenetics, Evandro Chagas Clinical Research Institute, Oswaldo Cruz Foundation, Rio de Janeiro, 21040-360, Brazil.
Zoilo P CamargoLaboratory of Medical Mycology, Clinical Hospital, Faculty of Medicine, Federal University of São Paulo, São Paulo, 04023-062, Brazil.
Rinaldo P MendesTropical Disease Department, Faculty of Medicine of Botucatu, Paulista State University, Botucatu, Brazil.
Anamaria M M PaniagoFaculty of Medicine, Federal University of Mato Grosso do Sul, Cidade Universitária s/n, Campo Grande, 79070-900, Brazil.
Universidade Federal de Mato Grosso do Sul · BRFundação Oswaldo Cruz · BRUniversidade Estadual Paulista (Unesp) · BRUniversidade Federal de São Paulo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWe estimated the occurrence rate of the booster phenomenon by using an intradermal test with 43 kDa glycoprotein in an endemic area of paracoccidioidomycosis in the central-west region of Brazil.

methodsIndividuals who had a negative result on a survey performed by using an intradermal test with 43 kDa glycoprotein in an endemic area of paracoccidioidomycosis underwent a second intradermal test after 10-15 days to determine the presence or absence of the booster phenomenon. Statistical analyses were performed using the Chi-square test, Chi-square for linear trend test, Student's t test, and binomial test; p < 0.05 was considered significant.

resultsFor the first time, we reported the occurrence of the booster phenomenon to an intradermal reaction caused by 43 kDa glycoprotein at a rate of 5.8-8.4%, depending on the test's cutoff point. This suggests that a cutoff point should be considered for the booster phenomenon in intradermal tests with 43 kDa glycoprotein: a difference of 6-7 mm between readings according to the first and second tests, depending on the purpose of the evaluation.

conclusionThe results indicate that the prevalence of paracoccidioidal infection in endemic areas is underestimated, as the booster phenomenon has not been considered in epidemiological surveys for this infection.

Indexed as

AdultAgedAntigens, FungalBrazilEndemic DiseasesFemaleFungal ProteinsGlycoproteinsHumansImmunization, SecondaryMaleMiddle AgedParacoccidioidomycosisPrevalenceSkin Tests43 kDa protein, ParacoccidioidesAntigens, FungalFungal ProteinsGlycoproteinsBooster phenomenongp43Intradermal testsParacoccidioides brasiliensisParacoccidioidic infectionParacoccidioidomycosis

Identifiers

PMID28646277
OpenAlexW2628568385

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.