ArticleScientific reports2017
Efficient and unbiased metagenomic recovery of RNA virus genomes from human plasma samples.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed.
- Unveiling pathogens and contaminants: refining metagenomics for clinical diagnostics.Frontiers in microbiology · 2026Article
- Viral metagenomic analysis of fecal samples fromFrontiers in cellular and infection microbiology · 2025Article
- Virome profiling of fig wasps (Ceratosolen spp.) reveals virus diversity spanning four realms.Virology · 2024Article
- Full annotation of viral metagenomics in different components from Chinese blood donors using next-generation sequencing.Blood transfusion = Trasfusione del sangue · 2024Article
- Genomic characterization of respiratory syncytial virus genotypes circulating in the paediatric population of Sydney, NSW, Australia.Microbial genomics · 2023Article
- Evaluation of extraction and enrichment methods for recovery of respiratory RNA viruses in a metagenomics approach.Journal of virological methods · 2023Article
- Metagenomic next-generation sequencing and proteomics analysis in pediatric viral encephalitis and meningitis.Frontiers in cellular and infection microbiology · 2023Article
- The clinical application of metagenomic next-generation sequencing in infectious diseases at a tertiary hospital in China.Frontiers in cellular and infection microbiology · 2022Observational
- Detection of Japanese Encephalitis by Metagenomic Next-Generation Sequencing of Cerebrospinal Fluid: A Case Report and Literature Review.Frontiers in cellular neuroscience · 2022Article
- Targeting RNA with Next- and Third-Generation Sequencing Improves Pathogen Identification in Clinical Samples.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Article
- Microbial metagenomic approach uncovers the first rabbit haemorrhagic disease virus genome in Sub-Saharan Africa.Scientific reports · 2021Article
- Nucleic Acid Testing of SARS-CoV-2.International journal of molecular sciences · 2021Review
- Rapid viral metagenomics using SMART-9N amplification and nanopore sequencing.Wellcome open research · 2021Article
- Assessing Genome-Wide Diversity in European Hantaviruses through Sequence Capture from Natural Host Samples.Viruses · 2020Article
- Human Tibroviruses: Commensals or Lethal Pathogens?Viruses · 2020Review
- Enhanced Detection of DNA Viruses in the Cerebrospinal Fluid of Encephalitis Patients Using Metagenomic Next-Generation Sequencing.Frontiers in microbiology · 2020Article
- Commensal viruses maintain intestinal intraepithelial lymphocytes via noncanonical RIG-I signaling.Nature immunology · 2019Article
- Review
- Metagenomic Sequencing of HIV-1 in the Blood and Female Genital Tract Reveals Little Quasispecies Diversity during Acute Infection.Journal of virology · 2019Observational
- Potential for diagnosis of infectious disease from the 100,000 Genomes Project Metagenomic Dataset: Recommendations for reporting results.Wellcome open research · 2019Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
RNA viruses cause significant human pathology and are responsible for the majority of emerging zoonoses. Mainstream diagnostic assays are challenged by their intrinsic diversity, leading to false negatives and incomplete characterisation. New sequencing techniques are expanding our ability to agnostically interrogate nucleic acids within diverse sample types, but in the clinical setting are limited by overwhelming host material and ultra-low target frequency. Through selective host RNA depletion and compensatory protocol adjustments for ultra-low RNA inputs, we are able to detect three major blood-borne RNA viruses - HIV, HCV and HEV. We recovered complete genomes and up to 43% of the genome from samples with viral loads of 10
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