ArticleScientific reports2017
Selective inhibition of sterolO-acyltransferase 1 isozyme by beauveriolide III in intact cells.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 21 citations in OpenAlex.
- Drimane sesquiterpene esters produced by Aspergillus insuetus BF-1613 as inhibitors of sterol O-acyltransferase.The Journal of antibiotics · 2024Article
- A pan-cancer analysis identifies SOAT1 as an immunological and prognostic biomarker.Oncology research · 2023Article
- Genomic and Experimental Analysis of the Insecticidal Factors Secreted by the Entomopathogenic FungusJournal of fungi (Basel, Switzerland) · 2022Article
- Combined Lipidomics and Network Pharmacology Study of Protective Effects ofEvidence-based complementary and alternative medicine : eCAM · 2021Article
- Voluhemins, new inhibitors of sterol O-acyltransferase, produced by Volutella citrinella BF-0440.The Journal of antibiotics · 2020Article
- Production of Diverse Beauveriolide Analogs in Closely Related Fungi: a Rare Case of Fungal Chemodiversity.mSphere · 2020Article
- Review
- Celludinones, new inhibitors of sterol O-acyltransferase, produced by Talaromyces cellulolyticus BF-0307.The Journal of antibiotics · 2018Article
- Structural Diversity and Biological Activities of Cyclic Depsipeptides from Fungi.Molecules (Basel, Switzerland) · 2018Review
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Beauveriolide III (BeauIII) inhibited sterol O-acyltransferases 1 and 2 (SOAT1 and SOAT2), which are endoplasmic reticulum (ER) membrane proteins, in an enzyme-based assay, and selectively inhibited SOAT1 in a cell-based assay using SOAT1-/SOAT2-CHO cells. This discrepancy in SOAT inhibition by BeauIII was investigated. In the enzyme-based assay, BeauIII inhibited SOAT1 and SOAT2 to a similar extent using microsomes prepared from cells disrupted under the strongest sonication condition. In semi-intact SOAT1-/SOAT2-CHO cells prepared by a treatment with digitonin (plasma membrane permeabilized), BeauIII selectively inhibited SOAT1 (IC
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.