Evidence map›Paper›PMID 28646109›Full record

ArticleThe Journal of biological chemistry2017

Bone morphogenetic protein 9 (BMP9) and BMP10 enhance tumor necrosis factor-α-induced monocyte recruitment to the vascular endothelium mainly via activin receptor-like kinase 2.

Claudia-Gabriela Mitrofan, Sarah L Appleby, Gerard B Nash, Ziad Mallat, Edwin R Chilvers, Paul D Upton, Nicholas W Morrell

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 56 citations in OpenAlex.

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  10. An emerging class of new therapeutics targeting TGF, Activin, and BMP ligands in pulmonary arterial hypertension.Developmental dynamics : an official publication of the American Association of Anatomists · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Claudia-Gabriela MitrofanFrom the Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge CB2 0QQ and.
Sarah L ApplebyFrom the Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge CB2 0QQ and.
Gerard B Nashthe Institute of Cardiovascular Sciences, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom.
Ziad MallatFrom the Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge CB2 0QQ and.
Edwin R ChilversFrom the Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge CB2 0QQ and.
Paul D UptonFrom the Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge CB2 0QQ and.
Nicholas W MorrellFrom the Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge CB2 0QQ and nwm23@cam.ac.uk.
Cambridge School · PTUniversity of Cambridge · GBUniversity of Birmingham · GB

Funding

British Heart Foundation RG/13/4/30107Medical Research Council MR/K020919/1Medical Research Council MR/KR020919/1Wellcome TrustWellcome Trust 099824/Z/12/Z
6 · The paper itself

Abstract

Bone morphogenetic proteins 9 and 10 (BMP9/BMP10) are circulating cytokines with important roles in endothelial homeostasis. The aim of this study was to investigate the roles of BMP9 and BMP10 in mediating monocyte-endothelial interactions using an

Indexed as

Activin Receptors, Type IActivin Receptors, Type IIAortaBone Morphogenetic ProteinsCell AdhesionCells, CulturedEndothelium, VascularE-SelectinGrowth Differentiation Factor 2Growth Differentiation FactorsHumansIntercellular Adhesion Molecule-1KineticsMonocytesPhosphorylationProtein Kinase InhibitorsActivin Receptors, Type IActivin Receptors, Type IIACVR1 protein, humanACVRL1 protein, humanBMP10 protein, humanBone Morphogenetic ProteinsE-SelectinGDF2 protein, humanGrowth Differentiation Factor 2Growth Differentiation FactorsICAM1 protein, humanIntercellular Adhesion Molecule-1LDN 193189Protein Kinase InhibitorsPyrazolesPyrimidinesSELE protein, humanTNF protein, humanTumor Necrosis Factor-alphaVascular Cell Adhesion Molecule-1atherosclerosisbone morphogenetic protein (BMP)endothelial cellmonocyteSMAD transcription factor

Identifiers

PMID28646109
PMCPMC5566526
OpenAlexW2684055556

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.