ArticleBMJ open2017
Does depression increase the risk of stroke in patients with rheumatoid arthritis? A population-based cohort study.
Article in BMJ open, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.
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Who cites it
7 citing papers in PubMed, 2 syntheses or guidelines pooled it, 12 citations in OpenAlex.
- Association between psychiatric disorders and the risk of stroke: a meta-analysis of cohort studies.Frontiers in neurology · 2024Pooled it
- Association between depression and stroke risk in adults: a systematic review and meta-analysis.Frontiers in neurology · 2024Pooled it
- Hypertension in autoimmune rheumatic diseases: progress made, gaps remain.Journal of hypertension · 2026Article
- Mediating Role of Self-Efficacy in the Association Between Fatigue and Depressive Symptoms in Females with Rheumatoid Arthritis.Medicina (Kaunas, Lithuania) · 2025Article
- Traditional Chinese Medicine Body Constitutions as Predictors for Depression: A Systematic Review and Meta-Analysis.Behavioral sciences (Basel, Switzerland) · 2022Review
- Role of depressive symptoms in the health-related quality of life of Venezuelan patients with rheumatoid arthritis. Results from a tertiary care center.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2020Article
- Association of Use of Rehabilitation Services With Development of Dementia Among Patients With Rheumatoid Arthritis: Analysis of Domestic Data in Taiwan.Frontiers in medicine · 2020Article
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Authors and funding
6 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesComorbid depression is common and undertreated in patients with rheumatoid arthritis (RA). It remains uncertain whether comorbid depression provoked the risk of poor clinical outcome, stroke in particular, among patients with RA. This work aimed to determine if depression onset during the treatment process increases stroke risk for patients with RA as compared with those with (1) neither RA nor depression, (2) RA only and (3) depression only.
designA nationwide, population-based cohort study.
settingTaiwan's Longitudinal Health Insurance Database.
participantsWe identified 8045 subjects with a newly diagnosed RA between 1997 and 2010, together with 32 600 subjects without RA matched by age, gender and index date. All subjects were further divided into four groups based on whether they were diagnosed with comorbid depression during the follow-up period.
main outcome measureThe incidence rate and HR for incident stroke were estimated by the end of 2012 using Cox proportional hazard regression.
resultsWe discovered that patients with RA with the comorbid depression exhibited the highest risk of stroke, with an adjusted HR of 2.18 (95% CI 1.87 to 2.54). Those with RA only or those with depression only still had the higher risk of stroke by 43% and 57% as compared with subjects without either condition. Multivariate analysis showed RA subjects who were male or older, incurred the onset of depression, or had comorbidities such as hypertension, diabetes as well as heart disease, had a greater risk of stroke.
conclusionsThis study cleared up the significant association between RA and the subsequent risk of stroke, and further highlighted that the onset of depression within the treatment process may increase stroke risk for RA subjects. Findings could assist healthcare providers to pinpoint individuals with RA with a higher predisposition of stroke, which could facilitate the provision of appropriate rehabilitation.
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