Evidence map›Paper›PMID 28646078›Full record

ArticleDrug metabolism and disposition: the biological fate of chemicals2017

Stereospecific Metabolism of

Dustyn A Barnette, Bryce P Johnson, Dakota L Pouncey, Robert Nshimiyimana, Linda P Desrochers, Thomas E Goodwin, Grover P Miller

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Drug metabolism and disposition: the biological fate of chemicals, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Dustyn A BarnetteDepartment of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock (D.A.B., D.L.P., G.P.M.), Department of Chemistry, University of Central Arkansas, Conway (B.P.J.), and Department of Chemistry, Hendrix College, Conway (R.N., L.P.D., T.E.G.), Arkansas.
Bryce P JohnsonDepartment of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock (D.A.B., D.L.P., G.P.M.), Department of Chemistry, University of Central Arkansas, Conway (B.P.J.), and Department of Chemistry, Hendrix College, Conway (R.N., L.P.D., T.E.G.), Arkansas.
Dakota L PounceyDepartment of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock (D.A.B., D.L.P., G.P.M.), Department of Chemistry, University of Central Arkansas, Conway (B.P.J.), and Department of Chemistry, Hendrix College, Conway (R.N., L.P.D., T.E.G.), Arkansas.
Robert NshimiyimanaDepartment of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock (D.A.B., D.L.P., G.P.M.), Department of Chemistry, University of Central Arkansas, Conway (B.P.J.), and Department of Chemistry, Hendrix College, Conway (R.N., L.P.D., T.E.G.), Arkansas.
Linda P DesrochersDepartment of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock (D.A.B., D.L.P., G.P.M.), Department of Chemistry, University of Central Arkansas, Conway (B.P.J.), and Department of Chemistry, Hendrix College, Conway (R.N., L.P.D., T.E.G.), Arkansas.
Thomas E GoodwinDepartment of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock (D.A.B., D.L.P., G.P.M.), Department of Chemistry, University of Central Arkansas, Conway (B.P.J.), and Department of Chemistry, Hendrix College, Conway (R.N., L.P.D., T.E.G.), Arkansas.
Grover P MillerDepartment of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock (D.A.B., D.L.P., G.P.M.), Department of Chemistry, University of Central Arkansas, Conway (B.P.J.), and Department of Chemistry, Hendrix College, Conway (R.N., L.P.D., T.E.G.), Arkansas MillerGroverP@uams.edu.
University of Central Arkansas · USHendrix College · USUniversity of Arkansas for Medical Sciences · US

Funding

Arkansas Center for Clinical and Translational ResearchUL1TR000039 · NCATS · UNIV OF ARKANSAS FOR MED SCIS · PI BECK, CORNELIA MARIE, JAMES, LAURA P · 2012 to 2014
$10.0M
DATA AND TOOLS FOR MODELING METABOLISM AND REACTIVITYR01LM012222 · NLM · WASHINGTON UNIVERSITY · PI MILLER, GROVER P, SWAMIDASS, SANJAY JOSHUA · 2016 to 2019
$1.5M
Computationally modeling the impact of ontogeny on drug metabolic fateR01LM012482 · NLM · UNIV OF ARKANSAS FOR MED SCIS · PI MILLER, GROVER P, SWAMIDASS, SANJAY JOSHUA · 2016 to 2019
$1.3M
UAMS Summer Undergraduate Research Program to Increase Diversity in Research- ResubmissionR25HL108825 · NHLBI · UNIV OF ARKANSAS FOR MED SCIS · PI MCGEHEE, ROBERT E, THOMAS, BILLY R · 2011 to 2025
$1.2M
NCATS NIH HHS UL1 TR000039NHLBI NIH HHS R25 HL108825NLM NIH HHS R01 LM012222NLM NIH HHS R01 LM012482
6 · The paper itself

Abstract

Coumadin (rac-warfarin) is the most commonly used anticoagulant in the world; however, its clinical use is often challenging because of its narrow therapeutic range and interindividual variations in response. A critical contributor to the uncertainty is variability in warfarin metabolism, which includes mostly oxidative but also reductive pathways. Reduction of each warfarin enantiomer yields two warfarin alcohol isomers, and the corresponding four alcohols retain varying levels of anticoagulant activity. Studies on the kinetics of warfarin reduction have often lacked resolution of parent-drug enantiomers and have suffered from coelution of pairs of alcohol metabolites; thus, those studies have not established the importance of individual stereospecific reductive pathways. We report the first steady-state analysis of

Indexed as

AnticoagulantsChromatography, High Pressure LiquidCytosolHumansKineticsLiverOxidoreductasesStereoisomerismStructure-Activity RelationshipWarfarinAnticoagulantsOxidoreductasesWarfarin

Identifiers

PMID28646078
PMCPMC5539582
OpenAlexW2664149167

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.