Evidence map›Paper›PMID 28646043›Full record

ArticleGenetics2017

An Efficient FLP-Based Toolkit for Spatiotemporal Control of Gene Expression in

Celia Muñoz-Jiménez, Cristina Ayuso, Agnieszka Dobrzynska, Antonio Torres-Mendéz, Patricia de la Cruz Ruiz, Peter Askjaer

Open access · bronzeAbstract read
In one paragraph

Article in Genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 69 citations in OpenAlex.

  1. Article
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  7. TAG-IN, a swappable strategy for endogenous gene tagging inbioRxiv : the preprint server for biology · 2026
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  8. Article
  9. WormTagDB: A Systematic Survey of Endogenously Tagged Proteins inbioRxiv : the preprint server for biology · 2025
    Article
  10. AnalysisbioRxiv : the preprint server for biology · 2025
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  12. Review
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  20. Active Zone Trafficking of CaV2/UNC-2 Channels Is Independent of β/CCB-1 and α2δ/UNC-36 Subunits.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Celia Muñoz-JiménezAndalusian Center for Developmental Biology (CABD), CSIC/JA/Universidad Pablo de Olavide, 41013 Seville, Spain.
Cristina AyusoAndalusian Center for Developmental Biology (CABD), CSIC/JA/Universidad Pablo de Olavide, 41013 Seville, Spain.
Agnieszka DobrzynskaAndalusian Center for Developmental Biology (CABD), CSIC/JA/Universidad Pablo de Olavide, 41013 Seville, Spain.
Antonio Torres-MendézAndalusian Center for Developmental Biology (CABD), CSIC/JA/Universidad Pablo de Olavide, 41013 Seville, Spain.ORCID 0000-0002-1241-8629
Patricia de la Cruz RuizAndalusian Center for Developmental Biology (CABD), CSIC/JA/Universidad Pablo de Olavide, 41013 Seville, Spain.
Peter AskjaerAndalusian Center for Developmental Biology (CABD), CSIC/JA/Universidad Pablo de Olavide, 41013 Seville, Spain pask@upo.es.ORCID 0000-0003-3192-4428
Centro Andaluz de Biología del Desarrollo · ESUniversidad Pablo de Olavide · ESCentre for Genomic Regulation · ES

Funding

WormBase: a core data resource for C. elegans and other nematodesU41HG002223 · NHGRI · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI KERSEY, PAUL, SCHEDL, TIM · 2013 to 2017
$20.5M
Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
NHGRI NIH HHS U41 HG002223NIH HHS P40 OD010440
6 · The paper itself

Abstract

Site-specific recombinases are potent tools to regulate gene expression. In particular, the Cre (cyclization recombination) and FLP (flipase) enzymes are widely used to either activate or inactivate genes in a precise spatiotemporal manner. Both recombinases work efficiently in the popular model organism

Indexed as

Gene Expression Regulation, DevelopmentalAnimalsBacterial ProteinsCaenorhabditis elegansDNA NucleotidyltransferasesGenes, ReporterGenetic EngineeringIntegrasesIntestinal MucosaMuscle, SkeletalNeuronsRecombination, GeneticTransgenesBacterial ProteinsCre recombinaseDNA NucleotidyltransferasesFLP recombinaseIntegrasesbaf-1DamIDFLP-out gene inactivationgenome engineeringMosSCIPEEL-1 toxintissue-specific gene expression

Identifiers

PMID28646043
PMCPMC5560786
OpenAlexW2949872535

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.