Evidence map›Paper›PMID 28645897›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2017

Versatility of presenilin 1.

Georgia R Frost, Eitan Wong, Yue-Ming Li

Abstract readComment
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Georgia R FrostChemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065.
Eitan WongChemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065.
Yue-Ming LiChemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065; liy2@mskcc.org.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
Regulation and Function of Gamma-SecretaseR01AG026660 · NIA · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI LI, YUEMING · 2005 to 2015
$3.5M
Mechanism and therapy of AB-42-specific gamma-secretaseR01NS076117 · NINDS · SLOAN-KETTERING INST CAN RESEARCH · PI LI, YUEMING, ZHENG, HUI · 2011 to 2015
$2.8M
Mechanism and Synergy of gamma-Secretase ModulatorsR01NS096275 · NINDS · SLOAN-KETTERING INST CAN RESEARCH · PI LI, YUEMING · 2016 to 2020
$2.1M
NCI NIH HHS P30 CA008748NIA NIH HHS R01 AG026660NINDS NIH HHS R01 NS076117NINDS NIH HHS R01 NS096275
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Presenilin-1Presenilin-2Alzheimer DiseasePresenilin-1Presenilin-2

Identifiers

PMID28645897
PMCPMC5502655

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.