ArticleProceedings of the National Academy of Sciences of the United States of America2017
Multiparity improves outcomes after cerebral ischemia in female mice despite features of increased metabovascular risk.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- Guidelines for assessing maternal cardiovascular physiology during pregnancy and postpartum.American journal of physiology. Heart and circulatory physiology · 2024Guideline
- Microchimerism in the Human Brain, Quantitative Assessment and Single Nuclei Profiling Establish Cell Types and Diversity.bioRxiv : the preprint server for biology · 2026Article
- Postpartum Plasma-Derived Exosomes Confer Mitochondrial Stabilization and Neuroprotection against Ischemic Stroke.Research square · 2026Article
- The effects of a second pregnancy on women's brain structure and function.Nature communications · 2026Article
- Microchimerism and pregnancy complications with placental dysfunction.Seminars in immunopathology · 2025Review
- The when, what, and where of naturally-acquired microchimerism.Seminars in immunopathology · 2025Review
- Effects of Sildenafil on Cognitive Function Recovery and Neuronal Cell Death Protection after Transient Global Cerebral Ischemia in Gerbils.Biomedicines · 2024Article
- Mitochondria-containing extracellular vesicles from mouse vs. human brain endothelial cells for ischemic stroke therapy.Journal of controlled release : official journal of the Controlled Release Society · 2024Article
- Central IRF4/5 Signaling Are Critical for Microglial Activation and Impact on Stroke Outcomes.Translational stroke research · 2024Article
- X, but not Y, Chromosomal Complement Contributes to Stroke Sensitivity in Aged Animals.Translational stroke research · 2023Article
- Contribution of fetal microchimeric cells to maternal wound healing in sickle cell ulcers.Haematologica · 2023Article
- Retinal Venule Coverage by Pericytes Decreases in Multiparous Mice in a Time-Dependent Manner Post-Delivery.International journal of molecular sciences · 2023Article
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- Mechanistic Insights into Selective Autophagy Subtypes in Alzheimer's Disease.International journal of molecular sciences · 2022Review
- Pregnancy, preeclampsia and maternal aging: From epidemiology to functional genomics.Ageing research reviews · 2022Review
- Repair of brain damage size and recovery of neurological dysfunction after ischemic stroke are different between strains in mice: evaluation using a novel ischemic stroke model.Experimental animals · 2021Article
- Forever Connected: The Lifelong Biological Consequences of Fetomaternal and Maternofetal Microchimerism.Clinical chemistry · 2021Review
- Neuroprotective Effects of Motherhood on Brain Function in Late Life: A Resting-State fMRI Study.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Advanced maternal age impacts physiologic adaptations to pregnancy in vervet monkeys.GeroScience · 2020Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
Females show a varying degree of ischemic sensitivity throughout their lifespan, which is not fully explained by hormonal or genetic factors. Epidemiological data suggest that sex-specific life experiences such as pregnancy increase stroke risk. This work evaluated the role of parity on stroke outcome. Age-matched virgin (i.e., nulliparous) and multiparous mice were subjected to 60 min of reversible middle cerebral artery occlusion and evaluated for infarct volume, behavioral recovery, and inflammation. Using an established mating paradigm, fetal microchimeric cells present in maternal mice were also tracked after parturition and stroke. Parity was associated with sedentary behavior, weight gain, and higher triglyceride and cholesterol levels. The multiparous brain exhibited features of immune suppression, with dampened baseline microglial activity. After acute stroke, multiparous mice had smaller infarcts, less glial activation, and less behavioral impairment in the critical recovery window of 72 h. Behavioral recovery was significantly better in multiparous females compared with nulliparous mice 1 mo after stroke. This recovery was accompanied by an increase in poststroke angiogenesis that was correlated with improved performance on sensorimotor and cognitive tests. Multiparous mice had higher levels of VEGF, both at baseline and after stroke. GFP
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.