ArticleDevelopmental biology2017
A population of G2-arrested cells are selected as sensory organ precursors for the interommatidial bristles of the Drosophila eye.
Article in Developmental biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 23 citations in OpenAlex.
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- Distinct developmental phenotypes result from mutation of Set8/KMT5A and histone H4 lysine 20 in Drosophila melanogaster.Genetics · 2022Article
- Hexagonal patterning of the Drosophila eye.Developmental biology · 2021Review
- Comparative transcriptome analyses of the Drosophila pupal eye.G3 (Bethesda, Md.) · 2021Article
- Role of Serotonin Transporter in Eye Development ofInternational journal of molecular sciences · 2020Article
- Nutrient restriction causes reversible G2 arrest inDevelopment (Cambridge, England) · 2019Article
- Cell Adhesion-Mediated Actomyosin Assembly Regulates the Activity of Cubitus Interruptus for Hematopoietic Progenitor Maintenance inGenetics · 2019Article
- Fate mapping during regeneration: Cells that undergo compensatory proliferation in damaged Drosophila eye imaginal discs differentiate into multiple retinal accessory cell types.Developmental biology · 2018Article
- The Notch pathway regulates the Second Mitotic Wave cell cycle independently of bHLH proteins.Developmental biology · 2017Article
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Abstract
Cell cycle progression and differentiation are highly coordinated during the development of multicellular organisms. The mechanisms by which these processes are coordinated and how their coordination contributes to normal development are not fully understood. Here, we determine the developmental fate of a population of precursor cells in the developing Drosophila melanogaster retina that arrest in G2 phase of the cell cycle and investigate whether cell cycle phase-specific arrest influences the fate of these cells. We demonstrate that retinal precursor cells that arrest in G2 during larval development are selected as sensory organ precursors (SOPs) during pupal development and undergo two cell divisions to generate the four-cell interommatidial mechanosensory bristles. While G2 arrest is not required for bristle development, preventing G2 arrest results in incorrect bristle positioning in the adult eye. We conclude that G2-arrested cells provide a positional cue during development to ensure proper spacing of bristles in the eye. Our results suggest that the control of cell cycle progression refines cell fate decisions and that the relationship between these two processes is not necessarily deterministic.
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