Evidence map›Paper›PMID 28645697›Full record

ArticleMagnetic resonance imaging2017

Clinical high-resolution mapping of the proteoglycan-bound water fraction in articular cartilage of the human knee joint.

Mustapha Bouhrara, David A Reiter, Kyle W Sexton, Christopher M Bergeron, Linda M Zukley, Richard G Spencer

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Magnetic resonance imaging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Steady-state double-angle method for rapid BMagnetic resonance in medicine · 2019
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mustapha BouhraraLaboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA. Electronic address: bouhraram@mail.nih.gov.
David A ReiterLaboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA. Electronic address: reiterda@nia.nih.gov.
Kyle W SextonLaboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA. Electronic address: kyle.sexton@nih.gov.
Christopher M BergeronLaboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA. Electronic address: christopher.bergeron@nih.gov.
Linda M ZukleyClinical Research Core, Office of the Scientific Director, National Institute on Aging, National Institutes of Health, Baltimore, MD 21225, USA. Electronic address: zukleylm@mail.nih.gov.
Richard G SpencerLaboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA. Electronic address: spencerri@mail.nih.gov.

Funding

Multicompartment quantification of tissue in vitro and in vivo with magnetic resonance imaging and spectroscopyZIAAG000930 · NIA · NATIONAL INSTITUTE ON AGING · PI SPENCER, RICHARD · 2015 to 2025
$11.6M
Intramural NIH HHS Z99 AG999999
6 · The paper itself

Abstract

purposeWe applied our recently introduced Bayesian analytic method to achieve clinically-feasible in-vivo mapping of the proteoglycan water fraction (PgWF) of human knee cartilage with improved spatial resolution and stability as compared to existing methods. MATERIALS AND

methodsMulticomponent driven equilibrium single-pulse observation of T

resultsUnlike SRC, the BMC-derived maps from the two HR datasets were essentially identical. Furthermore, SRC maps showed substantial random variation in estimated PgWF, and mean values that differed from those obtained using BMC. In addition, PgWF maps derived from conventional low-resolution (LR) datasets exhibited partial volume and magnetic susceptibility effects. These artifacts were absent in HR PgWF images. Finally, our analysis showed regional variation in PgWF estimates, and substantially higher values in the younger subjects as compared to the older subject.

conclusionsBMC-mcDESPOT permits HR in-vivo mapping of PgWF in human knee cartilage in a clinically-feasible acquisition time. HR mapping reduces the impact of partial volume and magnetic susceptibility artifacts compared to LR mapping. Finally, BMC-mcDESPOT demonstrated excellent reproducibility in the determination of PgWF.

Indexed as

AdultAged, 80 and overBayes TheoremCartilage, ArticularHumansImage Processing, Computer-AssistedKneeKnee InjuriesKnee JointMagnetic Resonance ImagingMaleMonte Carlo MethodProteoglycansReproducibility of ResultsStochastic ProcessesWaterProteoglycansWaterKnee cartilageMagnetic resonance imagingProteoglycan water fraction

Identifiers

PMID28645697
PMCPMC5632579

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.